Document Detail


Baseline values of candidate urine acute kidney injury biomarkers vary by gestational age in premature infants.
MedLine Citation:
PMID:  21646940     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped kidneys, baseline biomarker values may differ. We describe baseline values of urinary neutrophil gelatinase-associated lipocalin (NGAL), IL-18, kidney injury molecule-1 (KIM-1), osteopontin (OPN), beta-2 microglobulin (B2mG), and Cystatin-C (Cys-C). Next, we test the hypothesis that these biomarkers are inversely related to GA. Candidate markers were compared according to GA categories in 123 infants. Mixed linear regression models were performed to determine the independent association between demographics/interventions and baseline biomarker values. We found that urine NGAL, KIM-1, Cys-C, and B2mG decreased with increasing GA. With correction for urine creatinine (cr), these markers and OPN/cr decreased with increasing GA. IL-18 (with or without correction for urine creatinine) did not differ across GA categories. Controlling for other potential clinical and demographic confounders with regression analysis shows that NGAL/cr, OPN/cr, and B2mG/cr are independently associated with GA. We conclude that urine values of candidate AKI biomarkers are higher in the most premature infants. These findings should be considered when designing and analyzing biomarker studies in newborn with AKI.
Authors:
David J Askenazi; Rajesh Koralkar; Emily B Levitan; Stuart L Goldstein; Prasad Devarajan; Srikrishna Khandrika; Ravindra L Mehta; Namasivayam Ambalavanan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-08     Completed Date:  2011-12-06     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  302-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA. daskenazi@peds.uab.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Kidney Injury / diagnosis,  urine*
Biological Markers / urine*
Creatinine / blood,  urine
Female
Gestational Age*
Humans
Infant, Newborn / urine*
Infant, Premature / urine*
Infant, Very Low Birth Weight / urine*
Kidney Function Tests
Pregnancy
Grant Support
ID/Acronym/Agency:
P30 DK079337-04/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 60-27-5/Creatinine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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