Document Detail

The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in rectal carcinoma.
MedLine Citation:
PMID:  20127292     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of rectal cancer patients.
METHODS: Study participants were identified from a prospective cohort of patients with rectal cancer in Dalian of China (n = 123).
RESULTS: The median baseline N/L ratio was 2.41 +/- 2.206 (range, 0.76-20.45). Our results revealed that the N/L ratio was significantly associated with tumor size (P = 0.003) and level of cancer antigen 125 (P = 0.027). A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio, 2.615; 95% confidence interval, 1.152-5.933; P = 0.021).
CONCLUSIONS: These results suggest that the N/L ratio is an independent prognostic factor in rectal cancer, and the N/L ratio may serve as a clinically accessible and useful biomarker for patient survival.
Huanran Liu; Ge Liu; Quan Bao; Wei Sun; Haidong Bao; Liang Bi; Wei Wen; Yanfeng Liu; Zhenglin Wang; Xunguo Yin; Yunqing Bai; Xiang Hu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastrointestinal cancer     Volume:  41     ISSN:  1941-6636     ISO Abbreviation:  J Gastrointest Cancer     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-10-04     Revised Date:  2012-09-07    
Medline Journal Info:
Nlm Unique ID:  101479627     Medline TA:  J Gastrointest Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  IM    
Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
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MeSH Terms
Aged, 80 and over
China / epidemiology
Cohort Studies
Lymphocyte Count
Middle Aged
Neoplasm Staging
Proportional Hazards Models
Prospective Studies
Rectal Neoplasms / blood*,  classification,  mortality*,  pathology

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