| The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in rectal carcinoma. | |
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MedLine Citation:
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PMID: 20127292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of rectal cancer patients. METHODS: Study participants were identified from a prospective cohort of patients with rectal cancer in Dalian of China (n = 123). RESULTS: The median baseline N/L ratio was 2.41 +/- 2.206 (range, 0.76-20.45). Our results revealed that the N/L ratio was significantly associated with tumor size (P = 0.003) and level of cancer antigen 125 (P = 0.027). A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio, 2.615; 95% confidence interval, 1.152-5.933; P = 0.021). CONCLUSIONS: These results suggest that the N/L ratio is an independent prognostic factor in rectal cancer, and the N/L ratio may serve as a clinically accessible and useful biomarker for patient survival. |
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Authors:
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Huanran Liu; Ge Liu; Quan Bao; Wei Sun; Haidong Bao; Liang Bi; Wei Wen; Yanfeng Liu; Zhenglin Wang; Xunguo Yin; Yunqing Bai; Xiang Hu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastrointestinal cancer Volume: 41 ISSN: 1941-6636 ISO Abbreviation: J Gastrointest Cancer Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-10-04 Revised Date: 2012-09-07 |
Medline Journal Info:
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Nlm Unique ID: 101479627 Medline TA: J Gastrointest Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 116-20 Citation Subset: IM |
Affiliation:
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Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China. lhrlhr9050@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over China / epidemiology Cohort Studies Female Humans Lymphocyte Count Lymphocytes* Male Middle Aged Neoplasm Staging Neutrophils* Prognosis Proportional Hazards Models Prospective Studies Rectal Neoplasms / blood*, classification, mortality*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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