| Baseline MRI characteristics of patients at high risk for multiple sclerosis: results from the CHAMPS trial. Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevention Study. | |
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MedLine Citation:
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PMID: 12166504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The baseline MRI studies from the Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevention Study (CHAMPS) trial, a randomized, longitudinal, double-blind trial of 383 patients with a first acute clinical demyelinating event and evidence of prior subclinical demyelination on magnetic resonance imaging (MRI) of the brain, provides a large MRI database for patients likely in the earliest stages of multiple sclerosis (MS). High-resolution baseline MRIs revealed a median of 13 T2 lesions (maximum = 103 lesions) and 2.05 cm3 of T2 lesion volume (maximum 35.04 cm3), with 30% of patients having one or more enhancing lesions despite receiving a standardized high-dose course of intravenous corticosteroids. Periventricular, discrete, and juxtacortical T2 lesions were present in 99%, 92% and 67% of the patients, respectively. Large (> 6 mm), T1-hypointense, infratentorial, and corpus callosum lesions were present in 69%, 50%, 55% and 58%, respectively. Clinical presentation groups showed differences in T2 lesion volume, and enhancing lesion number and volume. At baseline, 97%, 81% and 72% of the patients met 'Paty', 'Fazekas', and 'Barkhof' research criteria for MS, respectively, with the percentages similar according to clinical presentation group. These results support and extend those of smaller and/or retrospective series, which have shown substantial subclinical injury, based on brain MRI, at the earliest identifiable stages of disease. |
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Authors:
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 8 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-08 Completed Date: 2003-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 330-8 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Databases, Factual Double-Blind Method Female Humans Longitudinal Studies Magnetic Resonance Imaging* Male Multiple Sclerosis / epidemiology, pathology* Optic Neuritis / epidemiology, pathology Risk Factors |
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