| Baseline Epidemiology of Streptococcus pneumoniae Serotypes in Canada Prior to the Introduction of the 13-Valent Pneumococcal Vaccine. | |
| | |
MedLine Citation:
|
PMID: 22204595 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Changes in the epidemiology of Streptococcus pneumoniae were reported worldwide after the introduction of the 7-valent pneumococcal vaccine, particularly an increase in multi-drug resistant (MDR) 19A strains. Subsequently, a 13-valent pneumococcal vaccine (PCV-13) has been introduced. This study assessed the incidence of S. pneumoniae serotypes in all age groups prior to the introduction of PCV-13 in Canada (2007-2009). Eight hundred S. pneumoniae isolates from respiratory specimens and blood cultures were collected as part of a Canadian surveillance study (CANWARD) from patients in 15 tertiary-care centers. Serotyping was performed by the Quellung method and antimicrobial susceptibility testing was performed by broth microdilution in accordance with the Clinical and Laboratory Standards Institute guidelines. The most common serotypes were 19A (8.6%), 3 (7.3%), 22F (6.0%), 4 (4.6%), 5 (4.4%), and 11A (4.4%); and the first serotype 6D isolate in Canada was identified. Serotypes 5, 7F, and 19A were significantly (p<0.001) more frequently isolated from bloodstream infections. Considerable serotype variability was noted for different age groups: 15B (p<0.01) and 19A (p<0.001) were more frequently isolated from children ≤2 years old. Overall, 46.4% of currently circulating S. pneumoniae serotypes in Canada are included in PCV-13. Notably, 87.5% of MDR-S. pneumoniae were covered by PCV-13. Accordingly, PCV-13 will provide coverage against a significant proportion of circulating S. pneumoniae strains in Canada, including the critical antimicrobial-resistant strains. |
| | |
Authors:
|
Heather J Adam; James A Karlowsky; Kimberly A Nichol; Matthew W Gilmour; Daryl J Hoban; Joanne Embree; George G Zhanel |
Related Documents
:
|
11132155 - A new method for quantitative analysis of the mouse t-cell receptor v region repertoire... 10325345 - Phylogenetic analysis of ara+ and ara- burkholderia pseudomallei isolates and developme... 8481015 - Comparison of chemical assay, bioassay, enzyme-linked immunosorbent assay, and dot blot... 12089305 - Pcr for detection of cdt-iii and the relative frequencies of cytolethal distending toxi... 11518895 - Defense factors of vaginal lactobacilli. 3069445 - Bacterial-induced diarrhoea. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
|
Title: Microbial drug resistance (Larchmont, N.Y.) Volume: - ISSN: 1931-8448 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508567 Medline TA: Microb Drug Resist Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Clinical Microbiology - Health Sciences Centre , Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Follicular Growth-Stimulated Cows Provide Favorable Oocytes for Producing Cloned Embryos.
Next Document: Antimicrobial Susceptibilities and Resistance Genes of Canadian Isolates of Actinobacillus pleuropne...