| Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons. | |
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MedLine Citation:
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PMID: 20827260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurovascular coupling associated with visual and vibrotactile stimulations in baboons anesthetized sequentially with isoflurane and ketamine was evaluated using multimodal functional magnetic resonance imaging (fMRI) on a clinical 3-Tesla scanner. Basal cerebral blood flow (CBF), and combined blood-oxygenation-level-dependent (BOLD) and CBF fMRI of visual and somatosensory stimulations were measured using pseudo-continuous arterial spin labeling. Changes in stimulus-evoked cerebral metabolic rate of oxygen (CMRO(2)) were estimated using calibrated fMRI. Arterial transit time for vessel, gray matter (GM), and white matter (WM) were 250, 570, and 823 ms, respectively. Gray matter and WM CBF, respectively, were 107.8±7.9 and 47.8±3.8 mL per 100 g per minute under isoflurane, and 108.8±10.3 and 48.7±4.2 mL per 100 g per minute under ketamine (mean±s.e.m., N=8 sessions, five baboons). The GM/WM CBF ratio was not statistically different between the two anesthetics, averaging 2.3±0.1. Hypercapnia evoked global BOLD and CBF increases. Blood-oxygenation-level-dependent, CBF, and CMRO(2) signal changes by visual and vibrotactile stimulations were 0.19% to 0.22%, 18% to 23%, and 4.9% to 6.7%, respectively. The CBF/CMRO(2) ratio was 2.9 to 4.7. Basal CBF and fMRI responses were not statistically different between the two anesthetics. This study establishes a multimodal fMRI protocol to probe clinically relevant functional, physiological and metabolic information in large nonhuman primates. |
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Authors:
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Hsiao-Ying Wey; Danny J Wang; Timothy Q Duong |
Publication Detail:
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Type: Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-08 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-03-17 Revised Date: 2012-02-10 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 715-24 Citation Subset: IM |
Affiliation:
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Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas 78229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Anesthesia Anesthetics, Dissociative Anesthetics, Inhalation Animals Brain / pathology Calibration Cerebrovascular Circulation / physiology* Female Hypercapnia / physiopathology Image Processing, Computer-Assisted Isoflurane Ketamine Kinetics Magnetic Resonance Imaging / methods* Oxygen / blood* Oxygen Consumption / physiology* Papio Perfusion Imaging Photic Stimulation Physical Stimulation Spin Labels Touch / physiology Vibration |
| Grant Support | |
ID/Acronym/Agency:
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MH080892/MH/NIMH NIH HHS; MH080892-S1/MH/NIMH NIH HHS; P41 RR002305-236856/RR/NCRR NIH HHS; R01 MH080892-01A2/MH/NIMH NIH HHS; R01 MH080892-01A2S1/MH/NIMH NIH HHS; R01 MH080892-02/MH/NIMH NIH HHS; R01 MH080892-03/MH/NIMH NIH HHS; R01 MH080892-04/MH/NIMH NIH HHS; R01 NS045879-08/NS/NINDS NIH HHS; UL1RR025767/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Dissociative; 0/Anesthetics, Inhalation; 0/Spin Labels; 26675-46-7/Isoflurane; 6740-88-1/Ketamine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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