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Baseline B-Type Natriuretic Peptide: A Gender-Specific Predictor of Procedure-Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation.
MedLine Citation:
PMID:  21371160     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Baseline BNP Predicts Ablation Outcome in Male AF Patients. Background: Close association between atrial fibrillation (AF) and brain natriuretic peptide (BNP) has been demonstrated by several studies. Important gender differences exist in AF patients including a higher plasma BNP level in women. Therefore, it is imperative to evaluate the relationship between AF and BNP separately in men and women. Objective: This study examined possible gender-specific role of BNP in predicting procedure outcome in AF patients undergoing catheter ablation. Method: The study population included 568 consecutive patients (age 62 ± 10, male 73%, paroxysmal 25%, persistent 38%, and long-standing persistent AF 37%) undergoing AF ablation, who had structurally normal heart and left ventricular ejection fraction ≥45%. Baseline BNP was measured in all. Patients were grouped into "normal" and "high" BNP based on gender-specific cut-off values (<50 and ≥50 pg/mL in males, <100 and ≥ 100 pg/mL in females). Result: Baseline BNP was significantly higher among women than men (126 ± 112 versus 87 ± 99, P = 0.009). At 12 ± 6 month follow-up, 304 of 414 (73%) males and 98 of 154 (64%) females were AF/atrial tachycardia-free off antiarrhythmic drugs (log-rank P = 0.018). In multivariable analysis, BNP remained an independent predictor of AF recurrence (BNP ≥ 50: hazard ratio [HR] 2.54, P = 0.006) in males. No such association was observed among females (BNP ≥ 100: HR 0.79, 95% CI 0.43-1.42; P = 0.426). Conclusion: Baseline BNP was found to be an independent predictor of AF recurrence in male patients undergoing ablation. This correlation between BNP and AF recurrence was not observed in females. Thus, BNP plays a gender-specific prognostic role in AF. (J Cardiovasc Electrophysiol, Vol. pp. 1-7).
Authors:
Sanghamitra Mohanty; Prasant Mohanty; Luigi DI Biase; Bai Rong; David Burkhardt; Joseph G Gallinghouse; Rodney Horton; Javier E Sanchez; Shane Bailey; Jason Zagrodzky; Andrea Natale
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-3
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  -     ISSN:  1540-8167     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
St. David's Medical Center, Texas Cardiac Arrhythmia Institute, Austin, Texas, USA School of Biological Sciences, University of Texas at Austin, Texas, USA Department of Cardiology, University of Foggia, Foggia, Italy Department of Biomedical Engineering, University of Texas at Austin, Texas, USA Department of Internal Medicine, Tong-Ji Hospital, Tong-Ji Medical College, Huazhong University of Science and Technology, Wuhan, China Division of Cardiology, Stanford University, Palo Alto, California, USA Interventional Electrophysiology, Scripps Clinic, San Diego, California, USA.
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