Document Detail


LC/MS Based Tools and Strategies on Qualitative and Quantitative Analysis of Herbal Components in Complex Matrixess.
MedLine Citation:
PMID:  22519370     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Accompanying with hot discussions on developing multi-target drugs for the therapy of multi-gene diseases, herbal medicines are receiving more and more attention from worldwide in both academic field and pharmaceutical industry. Pharmacokinetic and metabolic research is one of the important issues for intensive understanding of therapeutic benefits/risks of herbal medicines. Because of intrinsic complexity of the components contained in herbal medicines, the qualitative and quantitative analysis, which is a prerequisite for pharmacokinetic and metabolic evaluation of herbal medicines, remains a great challenge. This paper provides a review on the recent development of qualitative and quantitative methodologies on herbal medicines analysis. Powerful hybrid mass spectrometric tools such as Q-TOF and IT-TOF are highly useful for both the qualitative and quantitative analysis of complicated components. In the past decade, some universal useful strategies to qualitative and quantitative analysis and pharmacokinetic assessment of complicated herbal components have also been proposed. Nonetheless, it is urgent to develop more strategies in resolving the critical challenges such as the lack of authentic compounds, the difficulties in information processing, and the elimination of complex matrixes interferences.
Authors:
Liang Wu; Haiping Hao; Guangji Wang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Current drug metabolism     Volume:  -     ISSN:  1875-5453     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960533     Medline TA:  Curr Drug Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, China. hhp_770505@yahoo.com.cn.
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