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Basaloid squamous cell carcinoma with 'monster' cells: a mimic of pleomorphic basal cell carcinoma.
MedLine Citation:
PMID:  21039745     Owner:  NLM     Status:  In-Data-Review    
Pleomorphic giant or 'monster' cells represent a well-recognized yet uncommon finding associated with basal cell carcinoma (BCC), usually of nodular type. We present a case of basaloid squamous cell carcinoma (basaloid SCC) with 'monster' cells that closely mimicked those described in pleomorphic nodular BCC. Clinically, the lesion presented as a fleshy, hyperkeratotic nodule in an 82-year-old woman. Histopathology revealed a basaloid lesion with lobulated borders and focal retraction artifact but a lack of prominent palisading or stromal mucin. There were areas of necrosis and small foci of keratinization. Striking bizarre monstrous pleomorphic nuclei were widely scattered throughout the lesion. Ber-EP4 immunohistochemistry proved to be negative and epithelial membrane antigen (EMA) expression was moderate to strong in 70% of the basaloid epithelium. Monster cells have not previously been highlighted in cutaneous SCC or in its uncommon cutaneous basaloid variant. The prognostic significance of monster cells is unknown but, given the relative paucity of keratinization in basaloid SCC, these lesions should probably be regarded as poorly differentiated. We have not previously encountered an SCC that so closely resembles nodular BCC with pleomorphic monster cells and believe that this is the first such report in the literature. Defty CL, Segen J, Carter JJ, Ahmed I, Carr RA. Basaloid squamous cell carcinoma with 'monster' cells: a mimic of pleomorphic basal cell carcinoma.
Clare L Defty; Joseph Segen; Jonathan J Carter; Imtiaz Ahmed; Richard A Carr
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Publication Detail:
Type:  Journal Article     Date:  2010-10-05
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  38     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  354-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons A/S.
Department of Dermatology, University Hospitals of Coventry & Warwickshire NHS Trust, Clifford Bridge Road, Coventry, UK Pathology Laboratory, Warwick Hospital, Lakin Road, Warwick, UK.
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