Document Detail

Basaloid squamous carcinoma of oral cavity: a histologic and immunohistochemical study.
MedLine Citation:
PMID:  12167426     Owner:  NLM     Status:  MEDLINE    
Basaloid squamous carcinoma (BSC) is an aggressive variant of squamous cell carcinoma (SCC) with a predilection for the upper aerodigestive tract. In the English literature, approximately 40 cases of BSC have been described in the oral cavity. BSC has frequently been confused with adenoid cystic carcinoma (ACC), basal cell adenocarcinoma, and undifferentiated SCC. The purpose of the investigation was to examine the histological features and immunohistochemical expression of differentiation-related substances, including cytokeratin (CK) subtypes, vimentin, S-100, chromogranin, laminin, and type IV collagen, for the characterization of biological features of these tumours. We studied three cases of BSC of the oral cavity, three cases of ACC, and one case of basal cell adenocarcinoma. Well-differentiated and undifferentiated SCCs were also studied for comparison. The BSCs showed many histopathologic similarities to cases previously reported. Among the CK subtypes analyzed, CK14 was the only subtype expressed by all basaloid cells of BSC. Potentially useful for the differential diagnosis was the finding of CKs 7 and 19 expression in the basaloid cells of ACC, and CKs 7 and 8 in basal cell adenocarcinoma. In BSCs, laminin and type IV collagen were found in the microcystic spaces between basaloid cells, but neither ACCs nor basal cell adenocarcinoma showed this feature. These data suggest that immunohistochemical findings are helpful in distinguishing BSC of the oral cavity from other histopathologically similar tumours.
R D Coletta; P Cotrim; O P Almeida; V A F Alves; A Wakamatsu; P A Vargas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral oncology     Volume:  38     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-08-08     Completed Date:  2002-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  723-9     Citation Subset:  IM    
Department of Oral Pathology, University of Campinas Dental School, 13414-018 Piracicaba, São Paulo, Brazil.
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MeSH Terms
Adenocarcinoma / chemistry,  diagnosis,  pathology
Carcinoma, Adenoid Cystic / chemistry,  pathology
Carcinoma, Squamous Cell / chemistry,  pathology*
Carcinoma, Transitional Cell / chemistry,  pathology*
Diagnosis, Differential
Keratins / analysis
Mouth Neoplasms / chemistry,  pathology*
Reg. No./Substance:

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