Document Detail


Basal and postprandial substrate oxidation rates in obese women receiving two test meals with different protein content.
MedLine Citation:
PMID:  15297093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Fuel utilisation and storage in lean and obese subjects seem to be differently affected by the macronutrient distribution intake. The aim of this intervention study was to explore the extent to which the fat mass status and the macronutrient composition of an acute dietary intake influence substrate oxidation rates. METHODS: Fuel utilisation in 26 women, 14 obese (BMI = 37.1 +/- 1.1 kg/m2) and 12 lean (BMI = 20.6 +/- 0.5 kg/m2) was measured over 6 h to compare the metabolic effect of a single balanced protein (HC) meal and a high protein (HP) single meal, which were designed to supply similar energy contents (1672 kJ). The macronutrient composition as a percentage of energy of the HC meal was 55% carbohydrate, 15% protein and 30% fat, while the HP meal contained 40% carbohydrate, 30% protein and 30% fat. Nutrient oxidation rates and energy expenditure were calculated by indirect calorimetry (hood system), whereas exogenous amino acid oxidation was estimated from the 13C isotopic enrichment of breath after oral administration of L[1-13C]leucine. RESULTS: Fasting lipid oxidation was higher in the obese than in the lean women (P < 0.05), and it was significantly correlated with body fatness (P < 0.01). A single HP meal consumption produced higher postprandial fat oxidation as compared with HC meal intake (P < 0.02), in both obese and lean subjects, with no apparent changes in glucose oxidation rates. Furthermore, postprandial fat utilisation after the test meal intake was higher in obese than in the lean women (P < 0.01). The time course of 13CO2 in breath followed a similar pattern in both dietary groups, although a non-statistically significant higher trend in protein and 13C-leucine oxidation was found in the HP group. CONCLUSIONS: Net lipid oxidation depends on both short-term dietary composition intake and fat body mass, being significantly higher after a relatively high protein meal as compared to a balanced diet intake and in obese women as compared to lean controls.
Authors:
I Labayen; N Díez; D Parra; A González; J A Martínez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  23     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-06     Completed Date:  2005-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  571-8     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Ltd.
Affiliation:
Department of Physiology and Nutrition, University of Navarra, Irunlarrea, 1, 31008 Pamplona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Adult
Basal Metabolism / drug effects,  physiology*
Blood Glucose
Breath Tests
Calorimetry, Indirect
Carbon Isotopes
Dietary Carbohydrates / administration & dosage,  metabolism
Dietary Fats / administration & dosage,  metabolism
Dietary Proteins / administration & dosage*,  metabolism*
Dose-Response Relationship, Drug
Energy Metabolism / drug effects,  physiology*
Fasting
Female
Humans
Middle Aged
Obesity / metabolism*
Oxidation-Reduction
Postprandial Period
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Carbon Isotopes; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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