Document Detail

Basal and pentagastrin-stimulated levels of calcitonin in thyroid and peripheral veins during normocalcemia and chronic hypercalcemia in humans.
MedLine Citation:
PMID:  7259337     Owner:  NLM     Status:  MEDLINE    
The calcitonin secretion from the thyroid C-cells was studied with a peroperative method. The calcitonin concentrations in thyroid venous effluent and peripheral veins were determined in patients who underwent operations because of thyroid and parathyroid disease. In normocalcemia the thyroid vein level of calcitonin was significantly higher than that in peripheral vein. In chronic hypercalcemia no gradient over the thyroid was demonstrable. After injection of pentagastrin into a thyroid artery a very pronounced, but transient, increase in calcitonin concentration was registered. No difference in peak value between normo- and hypercalcemia was demonstrable. The peripheral vein level was unchanged. The peroperative method is very sensitive. A marked peak in thyroid vein corresponds to unchanged values in peripheral vein. The method invites further studies with other secretagogues and receptor-blocking substances.
M Ericsson; M Berg; S Ingemansson; B Jernby; J Järhult
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of surgery     Volume:  194     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  AIM; IM    
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MeSH Terms
Calcitonin / blood*,  secretion
Calcium / blood
Chronic Disease
Hypercalcemia / blood*
Middle Aged
Parathyroid Diseases / blood
Pentagastrin / diagnostic use*
Thyroid Diseases / blood
Thyroid Gland / blood supply,  secretion*
Thyroid Neoplasms / blood
Veins / analysis
Reg. No./Substance:
5534-95-2/Pentagastrin; 7440-70-2/Calcium; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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