Document Detail


Basal lamina: Schwann cells wrap to the rhythm of space-time.
MedLine Citation:
PMID:  16956757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schwann cells form myelin in the peripheral nervous system. All Schwann cells are surrounded by a basal lamina. Extracellular matrix molecules in the basal lamina, such as laminin, regulate key aspects of Schwann cell development including the formation, architecture and function of myelin. Recent genetic and cell biological experiments suggest that Schwann cells regulate the basal lamina and its receptors in both time and space, resulting in differential functions. These findings have important implications for diseases resulting from laminin dysfunction, such as congenital muscular dystrophy 1A.
Authors:
Felipe A Court; Lawrence Wrabetz; M Laura Feltri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-09-07
Journal Detail:
Title:  Current opinion in neurobiology     Volume:  16     ISSN:  0959-4388     ISO Abbreviation:  Curr. Opin. Neurobiol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-03     Completed Date:  2006-12-12     Revised Date:  2012-02-23    
Medline Journal Info:
Nlm Unique ID:  9111376     Medline TA:  Curr Opin Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-7     Citation Subset:  IM    
Affiliation:
San Raffaele Scientific Institute, Dipartimento di Ricerca Biologica e Tecnologica, Via Olgettina 58, Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basement Membrane / metabolism*
Collagen / metabolism
Extracellular Matrix / metabolism*
Humans
Laminin / metabolism
Myelin Sheath / metabolism*
Peripheral Nervous System / physiology*
Receptors, Cell Surface / metabolism
Schwann Cells / metabolism*
Grant Support
ID/Acronym/Agency:
GGP04019//Telethon; NS045630/NS/NINDS NIH HHS; NS055256/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Laminin; 0/Receptors, Cell Surface; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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