| Basal lamina: Schwann cells wrap to the rhythm of space-time. | |
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MedLine Citation:
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PMID: 16956757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Schwann cells form myelin in the peripheral nervous system. All Schwann cells are surrounded by a basal lamina. Extracellular matrix molecules in the basal lamina, such as laminin, regulate key aspects of Schwann cell development including the formation, architecture and function of myelin. Recent genetic and cell biological experiments suggest that Schwann cells regulate the basal lamina and its receptors in both time and space, resulting in differential functions. These findings have important implications for diseases resulting from laminin dysfunction, such as congenital muscular dystrophy 1A. |
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Authors:
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Felipe A Court; Lawrence Wrabetz; M Laura Feltri |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-09-07 |
Journal Detail:
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Title: Current opinion in neurobiology Volume: 16 ISSN: 0959-4388 ISO Abbreviation: Curr. Opin. Neurobiol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-03 Completed Date: 2006-12-12 Revised Date: 2012-02-23 |
Medline Journal Info:
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Nlm Unique ID: 9111376 Medline TA: Curr Opin Neurobiol Country: England |
Other Details:
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Languages: eng Pagination: 501-7 Citation Subset: IM |
Affiliation:
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San Raffaele Scientific Institute, Dipartimento di Ricerca Biologica e Tecnologica, Via Olgettina 58, Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basement Membrane / metabolism* Collagen / metabolism Extracellular Matrix / metabolism* Humans Laminin / metabolism Myelin Sheath / metabolism* Peripheral Nervous System / physiology* Receptors, Cell Surface / metabolism Schwann Cells / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GGP04019//Telethon; NS045630/NS/NINDS NIH HHS; NS055256/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Laminin; 0/Receptors, Cell Surface; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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