| Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation. | |
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MedLine Citation:
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PMID: 17620281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Manganese neurotoxicity in humans is recognized as a form of parkinsonism with lesions occurring predominantly within the globus pallidus, subthalamic nucleus, putamen, and caudate nucleus. METHODS: This study evaluated dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, norepinephrine, 5-hydroxyindoleacetic acid, gamma-aminobutyric acid (GABA), and glutamate concentrations in the globus pallidus, caudate, and putamen of male rhesus monkeys exposed subchronically to either air or manganese sulfate (MnSO4) at 0.06, 0.3, or 1.5 mg Mn/m3. RESULTS: An approximate 1.5-6-fold increase (vs. air-exposed controls) in mean brain manganese concentration was observed following subchronic MnSO4 exposure. A marginally significant (P < 0.1) decrease in pallidal GABA and 5-hydroxyindoleacetic acid concentration and caudate norepinephrine concentration occurred in monkeys exposed to MnSO4 at 1.5 mg Mn/m3. CONCLUSIONS: Despite the presence of increased tissue manganese concentrations, high-dose exposure to MnSO4 was associated with relatively few changes in basal ganglial neurotransmitter concentrations. |
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Authors:
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Melanie F Struve; Brian E McManus; Brian A Wong; David C Dorman |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of industrial medicine Volume: 50 ISSN: 0271-3586 ISO Abbreviation: Am. J. Ind. Med. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-18 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8101110 Medline TA: Am J Ind Med Country: United States |
Other Details:
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Languages: eng Pagination: 772-8 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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CIIT Centers for Health Research, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA. struve@ciit.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Animals Basal Ganglia / drug effects, metabolism* Disease Models, Animal Dopamine / metabolism Glutamic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Inhalation* Macaca mulatta Manganese Compounds / analysis Neurotransmitter Agents / analysis, metabolism* Norepinephrine / metabolism Parkinsonian Disorders / physiopathology* Serotonin / metabolism Sulfates / analysis, toxicity* gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Manganese Compounds; 0/Neurotransmitter Agents; 0/Sulfates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 7785-87-7/manganese sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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