Document Detail

Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study.
MedLine Citation:
PMID:  15229069     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study used 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia. METHOD: Nineteen schizophrenia patients and 31 age- and sex-matched healthy comparison subjects underwent (31)P MRS. RESULTS: The phosphocreatine/total phosphorus and phosphocreatine/total ATP ratios in both basal ganglia were significantly lower in patients. CONCLUSIONS: Schizophrenia patients showed features of increased metabolism in the basal ganglia consistent with impaired activity of the frontostriatal pathways.
B N Gangadhar; P N Jayakumar; D K Subbakrishna; N Janakiramaiah; M S Keshavan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  161     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-01     Completed Date:  2004-08-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1304-6     Citation Subset:  AIM; IM    
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, 560 029 Bangalore, India.
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MeSH Terms
Adenosine Triphosphate / metabolism
Antipsychotic Agents / administration & dosage
Basal Ganglia / metabolism*
Energy Metabolism
Magnetic Resonance Spectroscopy*
Neural Pathways / metabolism
Phosphates / metabolism*
Phosphocreatine / metabolism
Phosphorus / metabolism
Phosphorus Isotopes / diagnostic use
Schizophrenia / diagnosis*,  metabolism
Grant Support
1R43 04370-01A1//PHS HHS
Reg. No./Substance:
0/Antipsychotic Agents; 0/Phosphates; 0/Phosphorus Isotopes; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 7723-14-0/Phosphorus

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