| Basal follicle-stimulating hormone as a predictor of fetal aneuploidy. | |
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MedLine Citation:
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PMID: 18178189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether an elevated basal FSH concentration is an independent predictor of fetal aneuploidy, as measured in spontaneous abortions (SAB). DESIGN: Retrospective study. SETTING: Academic reproductive endocrinology and infertility center. PATIENT(S): All women with karyotypes of chorionic villi isolated from first trimester spontaneous miscarriages at the time of dilation and curettage from 1999 to 2006. The highest basal serum FSH level in the year preceding dilation and curettage was recorded. INTERVENTIONS(S): Monitoring of early pregnancy. MAIN OUTCOME MEASURE(S): Fetal karyotype. RESULTS(S): A total of 177 spontaneous miscarriages with karyotypes (70 euploid and 107 aneuploid) were identified, of which 53% were conceived by IVF. The aneuploid cohort consisted of trisomic (87%), teraploid (9.3%), and monosomic (3.7%) gestations. Using logistic regression analysis, basal FSH was not found to be independently predictive of an aneuploid gestation in our data set. CONCLUSION(S): Our data do not support the hypothesis that an elevated basal FSH concentration is associated with an increase in fetal aneuploidy. Our findings suggest that the association between diminished ovarian reserve and SAB may result from nonkaryotypic factors. |
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Authors:
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Jamie A M Massie; Richard O Burney; Amin A Milki; Lynn M Westphal; Ruth B Lathi |
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Publication Detail:
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Type: Journal Article Date: 2008-01-07 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2008-12-23 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2351-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, Stanford, California 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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genetics,
metabolism* Adult Aneuploidy* Biological Markers / blood Female Follicle Stimulating Hormone, Human / blood* Humans Karyotyping Logistic Models Predictive Value of Tests Pregnancy Retrospective Studies Risk Factors Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Follicle Stimulating Hormone, Human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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