| Basal cerebral blood volume during the poststimulation undershoot in BOLD MRI of the human brain. | |
| | |
MedLine Citation:
|
PMID: 20736964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
One of the characteristics of the blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) response to functional challenges of the brain is the poststimulation undershoot, which has been suggested to originate from a delayed recovery of either cerebral blood volume (CBV) or cerebral metabolic rate of oxygen to baseline. Using bolus-tracking MRI in humans, we recently showed that relative CBV rapidly normalizes after the end of stimulation. As this observation contradicts at least part of the blood-pool contrast agent studies performed in animals, we reinvestigated the CBV contribution by dynamic T1-weighted three-dimensional MRI (8 seconds temporal resolution) and Vasovist at 3 T (12 subjects). Initially, we determined the time constants of individual BOLD responses. After injection of Vasovist, CBV-related T1-weighted signal changes revealed a signal increase during visual stimulation (1.7% ± 0.4%), but no change relative to baseline in the poststimulation phase (0.2% ± 0.3%). This finding renders the specific nature of the contrast agent unlikely to be responsible for the discrepancy between human and animal studies. With the assumption of normalized cerebral blood flow after stimulus cessation, a normalized CBV lends support to the idea that the BOLD MRI undershoot reflects a prolonged elevation of oxidative metabolism. |
| | |
Authors:
|
Peter Dechent; Gunther Schütze; Gunther Helms; Klaus Dietmar Merboldt; Jens Frahm |
Related Documents
:
|
6838664 - Cardiovascular alterations in macaca monkeys exposed to stationary magnetic fields: exp... 19532334 - Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent ar... 2009564 - Analysis of high-frequency rotational angioplasty-induced echo contrast. 16528194 - Hemispheric revascularization in the setting of carotid occlusion and subclavian steal:... 9379424 - Immunohistochemical distribution of lymph capillaries and blood capillaries in the syno... 10362644 - Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in po... |
Publication Detail:
|
Type: Journal Article Date: 2010-08-25 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-04 Completed Date: 2011-02-03 Revised Date: 2012-01-02 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 82-9 Citation Subset: IM |
Affiliation:
|
MR-Research in Neurology and Psychiatry, Georg-August-Universität, Göttingen, Germany. pdechen@gwdg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Volume / physiology* Cerebrovascular Circulation / physiology* Contrast Media Data Interpretation, Statistical Female Gadolinium Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Male Organometallic Compounds Oxygen / blood* Photic Stimulation Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Organometallic Compounds; 0/gadofosveset trisodium; 7440-54-2/Gadolinium; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Parametric mapping of [18F]fluoromisonidazole positron emission tomography using basis functions.
Next Document: Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis.