| Basal cells of the human bronchiole. | |
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MedLine Citation:
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PMID: 6837307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basal cells of human bronchioles were studied by light and electron microscopic histochemistry, and compared with basal cells of major bronchi. Bronchiolar basal cells were found isolated or in isolated groups of a few linked cells. On the other hand, the basal cells of the major bronchi form virtually continuous layers covering the basement membrane. Bronchiolar basal cells were different in ultrastructure and alkaline phosphatase (ALP-ase) activity from basal cells of major bronchi. Bronchiolar basal cells showed intense ALP-ase activity on the plasma membrane, but basal cells of the major bronchi showed no activity. Basal cells of bronchioles were flattened, triangular or trapezoid in shape, and showed different organelle features from those of basal cells of major bronchi. ALP-ase positive bronchiolar flattened basal cells with pinocytoic vesicles were not myoepithelial cells, since actin was not demonstrated by immunohistochemistry. The role of basal cells in the renewal of epithelium appeared to be that of stem cells in both major bronchi and bronchioles, since basal cells of bronchioles appeared to differentiate directly to Clara cells, and to become ciliated cells via intermediate cells. |
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Authors:
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S Tamai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pathologica japonica Volume: 33 ISSN: 0001-6632 ISO Abbreviation: Acta Pathol. Jpn. Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372637 Medline TA: Acta Pathol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 123-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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analysis Alkaline Phosphatase / metabolism Basement Membrane / cytology* Bronchi / analysis, cytology*, enzymology, ultrastructure Epithelial Cells Histocytochemistry Humans Isoenzymes / metabolism Muscle, Smooth / analysis |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Isoenzymes; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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