| Basal cell carcinoma - molecular biology and potential new therapies. | |
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MedLine Citation:
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PMID: 22293184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. The realization that aberrant activation of Hedgehog signaling is a pathognomonic feature of BCC development has opened the way for exciting progress toward understanding BCC biology and translation of this knowledge to the clinic. Genetic mouse models closely mimicking human BCCs have provided answers about the tumor cell of origin, and inhibition of Hedgehog signaling is emerging as a potentially useful targeted therapy for patients with advanced or multiple BCCs that have hitherto lacked effective treatment. |
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Authors:
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Maria Kasper; Viljar Jaks; Daniel Hohl; Rune Toftgård |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-02-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-01 Completed Date: 2012-04-20 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 455-63 Citation Subset: AIM; IM |
Affiliation:
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Karolinska Institutet, Center for Biosciences and Department of Biosciences and Nutrition, Novum, Huddinge, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Basal Cell / etiology, pathology*, physiopathology*, therapy* Clinical Trials as Topic Disease Models, Animal Hedgehog Proteins / genetics, metabolism* Humans Molecular Biology Signal Transduction / physiology Skin / pathology, radiation effects Skin Neoplasms / etiology, pathology, physiopathology*, therapy* Ultraviolet Rays / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Hedgehog Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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