Document Detail


Basal adipose tissue and hepatic lipid kinetics are not affected by a single exercise bout of moderate duration and intensity in sedentary women.
MedLine Citation:
PMID:  18752466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertriacylglycerolaemia is an important risk factor for cardiovascular disease. In men, we have shown that the effects of evening exercise on basal VLDL (very-low-density lipoprotein) metabolism are dose-dependent: a single prolonged bout of aerobic exercise [2 h at 60% of VO(2 peak) (peak oxygen consumption)] reduces fasting plasma TAG [triacylglycerol (triglyceride)] concentrations, via enhanced clearance of VLDL-TAG from the circulation, whereas the same exercise performed for 1 h has no effect on VLDL-TAG metabolism and concentration. We hypothesized that women are more sensitive to the TAG-lowering effect of exercise because they reportedly use more intramuscular TAG as an energy source during exercise, and depletion of muscle TAG stores has been linked to reciprocal changes in skeletal muscle LPL (lipoprotein lipase) activity. To test our hypothesis, we measured basal VLDL-TAG and VLDL-apoB-100 (apolipoprotein B-100), and plasma NEFA [non-esterified fatty acid ('free fatty acid')] kinetics, by using stable isotope-labelled tracer techniques, on the morning after a single session of evening exercise of moderate duration and intensity (1 h at 60% of VO(2 peak)) in eight sedentary pre-menopausal women (age, 28+/-3 years; body mass index, 27+/-2 kg/m(2); body fat, 34+/-3%; values are means+/-S.E.M.). Compared with an equivalent period of evening rest, exercise had no effect on post-absorptive NEFA concentrations and the rate of appearance in plasma, VLDL-TAG and VLDL-apoB-100 concentrations, hepatic VLDL-TAG and VLDL-apoB-100 secretion and plasma clearance rates (all P>0.05). We conclude that, in women, as in men, a single session of exercise of moderate intensity and duration is not sufficient to bring about the alterations in VLDL metabolism that have been linked to post-exercise hypotriacylglycerolaemia.
Authors:
Faidon Magkos; Bruce W Patterson; B Selma Mohammed; Bettina Mittendorfer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  116     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-02-20     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adult
Apolipoprotein B-100 / blood
Exercise / physiology*
Fatty Acids, Nonesterified / blood
Female
Hormones / blood
Humans
Lipoproteins, VLDL / blood
Liver / metabolism*
Oxidation-Reduction
Oxygen Consumption / physiology
Pulmonary Gas Exchange / physiology
Rest / physiology
Triglycerides / blood
Workload
Grant Support
ID/Acronym/Agency:
AR 49869/AR/NIAMS NIH HHS; DK 56341/DK/NIDDK NIH HHS; M01 RR000036/RR/NCRR NIH HHS; M01 RR000036-441502/RR/NCRR NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; P30 DK056341-08/DK/NIDDK NIH HHS; P41 GM103422/GM/NIGMS NIH HHS; P41 RR000954/RR/NCRR NIH HHS; P41 RR000954-27S10255/RR/NCRR NIH HHS; P41 RR000954-31/RR/NCRR NIH HHS; R01 AR049869/AR/NIAMS NIH HHS; R01 AR049869-01A1/AR/NIAMS NIH HHS; RR 00036/RR/NCRR NIH HHS; RR 00954/RR/NCRR NIH HHS; UL1 RR 024992/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein B-100; 0/Fatty Acids, Nonesterified; 0/Hormones; 0/Lipoproteins, VLDL; 0/Triglycerides; 0/very low density lipoprotein triglyceride
Comments/Corrections

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