| Basal adipose tissue and hepatic lipid kinetics are not affected by a single exercise bout of moderate duration and intensity in sedentary women. | |
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MedLine Citation:
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PMID: 18752466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertriacylglycerolaemia is an important risk factor for cardiovascular disease. In men, we have shown that the effects of evening exercise on basal VLDL (very-low-density lipoprotein) metabolism are dose-dependent: a single prolonged bout of aerobic exercise [2 h at 60% of VO(2 peak) (peak oxygen consumption)] reduces fasting plasma TAG [triacylglycerol (triglyceride)] concentrations, via enhanced clearance of VLDL-TAG from the circulation, whereas the same exercise performed for 1 h has no effect on VLDL-TAG metabolism and concentration. We hypothesized that women are more sensitive to the TAG-lowering effect of exercise because they reportedly use more intramuscular TAG as an energy source during exercise, and depletion of muscle TAG stores has been linked to reciprocal changes in skeletal muscle LPL (lipoprotein lipase) activity. To test our hypothesis, we measured basal VLDL-TAG and VLDL-apoB-100 (apolipoprotein B-100), and plasma NEFA [non-esterified fatty acid ('free fatty acid')] kinetics, by using stable isotope-labelled tracer techniques, on the morning after a single session of evening exercise of moderate duration and intensity (1 h at 60% of VO(2 peak)) in eight sedentary pre-menopausal women (age, 28+/-3 years; body mass index, 27+/-2 kg/m(2); body fat, 34+/-3%; values are means+/-S.E.M.). Compared with an equivalent period of evening rest, exercise had no effect on post-absorptive NEFA concentrations and the rate of appearance in plasma, VLDL-TAG and VLDL-apoB-100 concentrations, hepatic VLDL-TAG and VLDL-apoB-100 secretion and plasma clearance rates (all P>0.05). We conclude that, in women, as in men, a single session of exercise of moderate intensity and duration is not sufficient to bring about the alterations in VLDL metabolism that have been linked to post-exercise hypotriacylglycerolaemia. |
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Authors:
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Faidon Magkos; Bruce W Patterson; B Selma Mohammed; Bettina Mittendorfer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 116 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-13 Completed Date: 2009-02-20 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 327-34 Citation Subset: IM |
Affiliation:
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Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Adult Apolipoprotein B-100 / blood Exercise / physiology* Fatty Acids, Nonesterified / blood Female Hormones / blood Humans Lipoproteins, VLDL / blood Liver / metabolism* Oxidation-Reduction Oxygen Consumption / physiology Pulmonary Gas Exchange / physiology Rest / physiology Triglycerides / blood Workload |
| Grant Support | |
ID/Acronym/Agency:
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AR 49869/AR/NIAMS NIH HHS; DK 56341/DK/NIDDK NIH HHS; M01 RR000036-441502/RR/NCRR NIH HHS; P30 DK056341-08/DK/NIDDK NIH HHS; P41 RR000954-27S10255/RR/NCRR NIH HHS; P41 RR000954-31/RR/NCRR NIH HHS; R01 AR049869-01A1/AR/NIAMS NIH HHS; RR 00036/RR/NCRR NIH HHS; RR 00954/RR/NCRR NIH HHS; UL1 RR 024992/RR/NCRR NIH HHS; UL1 RR024992-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein B-100; 0/Fatty Acids, Nonesterified; 0/Hormones; 0/Lipoproteins, VLDL; 0/Triglycerides; 0/very low density lipoprotein triglyceride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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