Document Detail


Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).
MedLine Citation:
PMID:  9494707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Impairments in both basal activity and activation of the hypothalamic-pituitary-adrenal axis (HPA) have been reported in chronic fatigue syndrome (CFS; neurasthenia). We sought to replicate these findings and examined basal activity of the HPA in a carefully selected sample of patients with CFS. METHODS: Basal activity of the HPA was assessed using salivary and urinary cortisol collection over a 24-hour period in 22 (12 male; 10 female) patients meeting criteria for CFS and appropriate controls. RESULTS: Salivary and urinary cortisol measures did not differ between CFS patients and controls. CONCLUSIONS: Basal activity of the HPA was not reduced in CFS patients. Reasons for the failure to replicate previous findings are discussed.
Authors:
A H Young; M Sharpe; A Clements; B Dowling; K E Hawton; P J Cowen
Related Documents :
22038617 - Cardiac arrest after spinal anesthesia in a patient with neurally mediated syncope.
7630247 - 3849+10 kb c-->t mutation and disease severity in cystic fibrosis.
21068277 - Analysis of the bacterial communities present in lungs of patients with cystic fibrosis...
12632377 - Resolution of hydrops fetalis in congenital cystic adenomatoid malformation after prena...
1652427 - Bilaterality of ulnar neuropathy at the elbow.
20431217 - Splenic artery embolisation for portal hypertension in children.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  43     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-30     Completed Date:  1998-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  236-7     Citation Subset:  IM    
Affiliation:
University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Fatigue Syndrome, Chronic / physiopathology*
Female
Humans
Hydrocortisone / metabolism,  urine
Hypothalamo-Hypophyseal System / physiopathology*
Male
Pituitary-Adrenal Function Tests
Pituitary-Adrenal System / physiopathology*
Radioimmunoassay
Saliva / metabolism
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reproducibility of plasma catecholamine metabolites in normal subjects.
Next Document:  Error analysis of chemically synthesized polynucleotides.