Document Detail

Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).
MedLine Citation:
PMID:  9494707     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Impairments in both basal activity and activation of the hypothalamic-pituitary-adrenal axis (HPA) have been reported in chronic fatigue syndrome (CFS; neurasthenia). We sought to replicate these findings and examined basal activity of the HPA in a carefully selected sample of patients with CFS. METHODS: Basal activity of the HPA was assessed using salivary and urinary cortisol collection over a 24-hour period in 22 (12 male; 10 female) patients meeting criteria for CFS and appropriate controls. RESULTS: Salivary and urinary cortisol measures did not differ between CFS patients and controls. CONCLUSIONS: Basal activity of the HPA was not reduced in CFS patients. Reasons for the failure to replicate previous findings are discussed.
A H Young; M Sharpe; A Clements; B Dowling; K E Hawton; P J Cowen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  43     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-30     Completed Date:  1998-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  236-7     Citation Subset:  IM    
University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom.
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MeSH Terms
Fatigue Syndrome, Chronic / physiopathology*
Hydrocortisone / metabolism,  urine
Hypothalamo-Hypophyseal System / physiopathology*
Pituitary-Adrenal Function Tests
Pituitary-Adrenal System / physiopathology*
Saliva / metabolism
Reg. No./Substance:

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