Document Detail

Basal, Circadian, and Acute Inflammation in Normal versus Overweight Men.
MedLine Citation:
PMID:  22776879     Owner:  NLM     Status:  Publisher    
Increased inflammation is present in obese compared to normal weight individuals, but inflammation characteristics of non-obese, overweight individuals are less clear. PURPOSE: To determine whether basal, circadian and post-eccentric exercise inflammation levels differ between normal and overweight men. METHODS: Men (18-35 y) classified as normal weight (BMI ≤ 25 kg·m, n=20) and overweight (BMI 25-30 kg·m, n=10) completed exercise (EX) and control (CON) conditions in random order. Maximal voluntary effort, eccentric actions (3x15) using the elbow flexor muscles of one arm were performed, and blood was collected pre-, 4, 8, 12, and 24 h post-exercise at 7:00 a.m., 12:00, 4:00, 8:00 p.m., and 7:00 a.m. Blood was collected on a time-matched schedule without exercise for CON. Soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin (IL)-6, C-reactive protein (CRP), and cortisol responses (EX value - time-matched CON value) were measured. RESULTS: Basal CRP was higher in the overweight compared to normal weight group (mean ± SD; 0.542 ± 0.578 versus 1.395 ± 1.041 mg·l). sTNFR1 increased (P<0.05) 8 h post-exercise in both groups and the response was greater 12 and 24 h post-exercise in the overweight compared to normal weight groups. IL-6 increased (P<0.05) 8 h post-exercise, with a trend (P=0.09) to be greater in the overweight group. CRP and cortisol responses were not detected. CONCLUSIONS: The low-grade inflammation state in overweight compared to normal weight men includes both higher basal CRP concentrations and enhanced acute inflammation, but not in changes to the circadian patterns of cortisol and inflammation variables.
Mary P Miles; Jan M Andring; Lindsay K Kordick; Jessy R Kidd
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Health and Human Development, Montana State University, Bozeman, Montana, USA.
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