| Basal cell carcinoma arising in a nevus sebaceus in a child with facial trichoepitheliomas. | |
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MedLine Citation:
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PMID: 20738793 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nevus sebaceus (NS) is a congenital skin hamartoma that presents in childhood. Tumors may arise within these lesions over time. Mutations in the PTCH gene have been associated with both NS and some of the developing tumors. Only nine documented cases of basal cell carcinoma arising in nevus sebaceus in childhood are available. We present a case of an 8-year-old male with nevus sebaceus who developed a basal cell carcinoma. Evaluation for constitutional PTCH gene mutation and loss of heterozygosity (LOH) from the BCC within the NS did not reveal an underlying mutation. We further discuss the literature regarding prophylactic excision of NS. |
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Authors:
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Allison L Jensen; Scott R Florell; Sheryll L Vanderhooft; Allen E Bale |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric dermatology Volume: 28 ISSN: 1525-1470 ISO Abbreviation: Pediatr Dermatol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406799 Medline TA: Pediatr Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 138-41 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah Pediatric Dermatology Clinic, Primary Children's Medical Center, Salt Lake City, Utah Department of Genetics, Yale School of Medicine, New Haven, Connecticut. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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