Document Detail


Barriers to cancer clinical trial participation among American Indian and Alaska Native tribal college students.
MedLine Citation:
PMID:  23289655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: American Indians and Alaska Natives (AIs/ANs) have some of the highest cancer-related mortality rates of all US racial and ethnic groups, but they are underrepresented in clinical trials. We sought to identify factors that influence willingness to participate in cancer clinical trials among AI/AN tribal college students, and to compare attitudes toward clinical trial participation among these students with attitudes among older AI/AN adults.
METHODS: Questionnaire data from 489 AI/AN tribal college students were collected and analyzed along with previously collected data from 112 older AI/AN adults. We examined 10 factors that influenced participation in the tribal college sample, and using chi-square analysis and these 10 factors, we compared attitudes toward research participation among 3 groups defined by age: students younger than 40, students 40 and older, and nonstudent adults 40 and older.
FINDINGS: About 80% of students were willing to participate if the study would lead to new treatments or help others with cancer in their community, the study doctor had experience treating AI/AN patients, and they received payment. Older nonstudent adults were less likely to participate on the basis of the doctor's expertise than were students (73% vs 84%, P = .007), or if the study was conducted 50 miles away (24% vs 41%, P= .001).
CONCLUSIONS: Finding high rates of willingness to participate is an important first step in increasing participation of AIs/ANs in clinical trials. More information is needed on whether these attitudes influence actual behavior when opportunities to participate become available.
Authors:
Debra Sprague; Joan Russo; Donna L LaVallie; Dedra Buchwald
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-24
Journal Detail:
Title:  The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association     Volume:  29     ISSN:  1748-0361     ISO Abbreviation:  J Rural Health     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-12-03     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  8508122     Medline TA:  J Rural Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Copyright Information:
© 2012 National Rural Health Association.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alaska
Attitude to Health / ethnology*
Clinical Trials as Topic / statistics & numerical data*
Female
Health Services Accessibility
Humans
Indians, North American* / statistics & numerical data
Inuits* / statistics & numerical data
Male
Neoplasms / ethnology*
Patient Participation / statistics & numerical data*
Questionnaires
Reproducibility of Results
Students
Universities
Young Adult
Grant Support
ID/Acronym/Agency:
5 T15 LM007442/LM/NLM NIH HHS; T15 LM007442/LM/NLM NIH HHS; U01 CA114642/CA/NCI NIH HHS; U01 CA114642/CA/NCI NIH HHS; UL1 RR025014/RR/NCRR NIH HHS; UL1RR025014/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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