| Barriers built on claudins. | |
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MedLine Citation:
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PMID: 15159449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fundamental functions of epithelia and endothelia in multicellular organisms are to separate compositionally distinct compartments and regulate the exchange of small solutes and other substances between them. Tight junctions (TJs) between adjacent cells constitute the barrier to the passage of ions and molecules through the paracellular pathway and function as a 'fence' within the plasma membrane to create and maintain apical and basolateral membrane domains. How TJs achieve this is only beginning to be understood. Recently identified components of TJs include the claudins, a family of four-transmembrane-span proteins that are prime candidates for molecules that function in TJ permeability. Their identification and characterization have provided new insight into the diversity of different TJs and heterogeneity of barrier functions in different epithelia and endothelia. |
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Authors:
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Kursad Turksen; Tammy-Claire Troy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of cell science Volume: 117 ISSN: 0021-9533 ISO Abbreviation: J. Cell. Sci. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-25 Completed Date: 2004-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: England |
Other Details:
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Languages: eng Pagination: 2435-47 Citation Subset: IM |
Affiliation:
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Ottawa Health Research Institute, Ontario K1Y 4E9, Canada. kturksen@ohri.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Motifs Amino Acid Sequence Animals Biological Transport Cell Membrane / chemistry* Cell Membrane Permeability Cell Polarity Conserved Sequence Evolution, Molecular Gene Expression Humans Membrane Proteins / chemistry*, genetics, metabolism* Models, Biological Molecular Sequence Data Molecular Weight Protein Structure, Tertiary Sequence Analysis, Protein Sequence Homology, Amino Acid Tight Junctions* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins |
| Comments/Corrections | |
Erratum In:
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J Cell Sci. 2004 Aug 15;117(Pt 18):4341 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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