Document Detail

Barrier mechanisms for neutrotransmitter monoamines in the choroid plexus.
MedLine Citation:
PMID:  6103637     Owner:  NLM     Status:  MEDLINE    
Studies were performed on choroid plexuses from mouse and rat. The plexus tissue, sympathectomized to avoid interference from adrenergic nerves, is able to accumulate L-DOPA as well as NA and 5-HT against a concentration gradient. Within the plexus tissue these compounds are metabolized by aromatic L-amino acid decarboxylase, MAO and COMT, whose activities were determined radiometrically. On the basis of this and the fate of systemically administered L-DOPA and DA studied by fluorescence histochemistry it is suggested that the epithelium of the choroid plexus provides not only a structural but also an enzymatic barrier for transmitter amines. The enzymatic barrier for amine precursors is considerably less sufficient at this blood-CSF interphase. The trapping of monoamines resembles the enzymatic barrier present in the endothelial cells and pericytes at the microvascular level of the blood-brain interphase.
M Lindvall; J E Hardebo; C Owman
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  108     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  215-21     Citation Subset:  IM    
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MeSH Terms
Aromatic-L-Amino-Acid Decarboxylases / metabolism*
Blood-Brain Barrier*
Catechol O-Methyltransferase / metabolism*
Choroid Plexus / enzymology*
Levodopa / metabolism
Monoamine Oxidase / metabolism*
Neurotransmitter Agents / metabolism*
Norepinephrine / metabolism
Serotonin / metabolism
Reg. No./Substance:
0/Levodopa; 0/Neurotransmitter Agents; 50-67-9/Serotonin; 51-41-2/Norepinephrine; EC Oxidase; EC O-Methyltransferase; EC Decarboxylases

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