Document Detail


Barrett's mucosa in conjunction with squamous carcinoma of the esophagus.
MedLine Citation:
PMID:  2065279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty esophagectomies (32 specimens with squamous cell carcinoma and 18 with adenocarcinoma) were reviewed for the presence of Barrett's mucosa. The whole resected specimens were cut, and a total of 1677 blocks (measuring up to 4.0 x 0.5 cm) were obtained. In resections with squamous cell carcinoma, a mean of 33.6 sections (range, 16 to 55 sections) were excised, and in those with adenocarcinomas, a mean of 33.4 sections (range, ten to 60 sections) were cut. Barrett's mucosa (without or with dysplasia) was present in all 18 specimens with an adenocarcinoma (100%) and in 13 of the 32 specimens (40.6%) with squamous cell carcinoma. In ten of the 13 specimens with squamous cell carcinoma, adjacent areas with high-grade squamous cell dysplasia were found. The squamous cell carcinoma and/or the adjacent squamous cell dysplasia were found separated from the Barrett's mucosa by normal squamous epithelium, supporting the view that these two lesions are not related to one another. Early clinical and experimental data showed that squamous cell dysplasia antedated the development of squamous cell carcinoma in that organ. One possible suggestive of these findings is that the detection of a Barrett's esophagus (without or with dysplasia) should prompt the endoscopist also to examine carefully the rest of the esophagus to exclude mucosal alterations possibly connected with squamous cell carcinogenesis in that organ.
Authors:
C A Rubio; B Aberg
Related Documents :
16021499 - Expression of p63 in conjunctival intraepithelial neoplasia and squamous cell carcinoma.
17660949 - Control of cell proliferation via elevated nedd8 conjugation in oral squamous cell carc...
15534869 - Paradigmatic identification of mmp-2 and mt1-mmp activation systems in cardiac fibrobla...
17513749 - Role of thrombospondin-1 in t cell response to ocular pigment epithelial cells.
12445139 - Carcinosarcoma of the esophagus characterized by myoepithelial and ductal differentiati...
20975919 - Lck, survivin and pi-3k in the molecular biomarker profiling of oral lichen planus and ...
11818059 - Drosophila e-cadherin regulates the orientation of asymmetric cell division in the sens...
24833089 - Overexpression of sox2 promotes migration, invasion, and epithelial-mesenchymal transit...
1708769 - Evidence that the gap junction protein connexin-43 is the atp-induced pore of mouse mac...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  68     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-15     Completed Date:  1991-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  583-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / complications,  pathology*,  surgery
Barrett Esophagus / complications,  pathology*,  surgery
Carcinoma, Squamous Cell / complications,  pathology*,  surgery
Esophageal Neoplasms / complications,  pathology*,  surgery
Humans
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The value of the tumor marker CA 15-3 in diagnosing and monitoring breast cancer. A comparative stud...
Next Document:  Candida tropicalis and Candida albicans fungemia in children with leukemia.