| Barrett's esophagus in females: a comparative analysis of risk factors in females and males. | |
| | |
MedLine Citation:
|
PMID: 15743352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Gastroesophageal reflux symptoms occur with similar frequency in males and females, yet Barrett's esophagus is less common in females. The reason for this disparity is unknown. The aim of this study was to determine the factors related to Barrett's in females. METHODS: The records of 796 patients (462 male, 334 female) evaluated from 1990 to 2000 for symptoms of reflux were retrospectively reviewed. Physiologic abnormalities based on results of endoscopic, motility, pH, and Bilitec testing were identified, and factors related to the presence of Barrett's were determined using univariate and multivariate analysis. RESULTS: Females with reflux symptoms were significantly less likely to have a positive 24-h pH test, a defective lower esophageal sphincter, or a hiatal hernia than males with reflux symptoms. Further, females with reflux on the basis of an abnormal 24-h pH test had significantly less esophageal acid exposure than males with reflux. In contrast, esophageal exposure to refluxed acid and bilirubin was similar in females (n = 50) and males (n = 136) with Barrett's. On multivariable analysis increased esophageal bilirubin exposure was the only significant factor associated with the presence of Barrett's in male and female patients with reflux disease. CONCLUSIONS: Females with reflux symptoms have less esophageal acid exposure on average than males. However, females and males with Barrett's have a similar severity of reflux, and the female gender does not protect against the development of Barrett's in the setting of advanced reflux disease. Esophageal bilirubin exposure is the major risk factor for the presence of Barrett's in patients with reflux disease. |
| | |
Authors:
|
Farzaneh Banki; Steven R Demeester; Rodney J Mason; Guilherme Campos; Jeffrey A Hagen; Jeffrey H Peters; Cedric G Bremner; Tom R Demeester |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 100 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-03-03 Completed Date: 2005-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 560-7 Citation Subset: IM |
Affiliation:
|
Department of Surgery and Cardiothoracic Surgery, Keck School of Medicine, The University of Southern California, Los Angeles, California, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Barrett Esophagus / etiology* Bilirubin / physiology Female Gastroesophageal Reflux / etiology Humans Hydrogen-Ion Concentration Male Middle Aged Retrospective Studies Risk Factors Sex Factors |
| Chemical | |
Reg. No./Substance:
|
635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux diseas...
Next Document: Age and sex distribution of the prevalence of Barrett's esophagus found in a primary referral endosc...