| Barotrauma and microvascular injury in lungs of nonadult rabbits: effect of ventilation pattern. | |
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MedLine Citation:
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PMID: 2344755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the pulmonary microvascular injury produced by ventilation barotrauma, the isolated perfused lungs of 4 to 6-wk-old New Zealand white rabbits were ventilated by one of the following methods: peak inspiratory pressure (PIP) 23 cm H2O, gas flow rate 1.1 L/min (group 1); PIP 27 cm H2O, gas flow rate 6.9 L/min (group 2); PIP 50 cm H2O, gas flow rate 1.9 L/min (group 3); or PIP 53 cm H2O, gas flow rate 8.3 L/min (group 4). Microvascular permeability was assessed using the capillary filtration coefficient (Kfc) before and 5, 30, and 60 min after a 15-min period of ventilation. Baseline Kfc was not significantly different between groups. A significant increase over the baseline Kfc was noted at 60 min in group 2 and in all postventilation Kfc values in groups 3 and 4 (p less than .05). Group 1 Kfc values did not change significantly after ventilation. At all post-ventilation times, values for Kfc were significantly greater in groups 3 and 4 than in group 1 (p less than .05). Group 4 Kfc values were significantly greater than those in group 2 at 5 and 30 min postventilation. These data indicate that high PIP, and to a lesser extent, high gas flow rates cause microvascular injury in the compliant nonadult lung and suggest that the combination of high PIP and high gas flow rates are the most threatening to microvascular integrity. |
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Authors:
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K J Peevy; L A Hernandez; A A Moise; J C Parker |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Critical care medicine Volume: 18 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-07-05 Completed Date: 1990-07-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 634-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of South Alabama, Mobile 36617. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Barotrauma / etiology, physiopathology* Capillary Permeability* Lung / blood supply, physiopathology Lung Injury* Pressure Rabbits Respiration, Artificial / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL-24571/HL/NHLBI NIH HHS; HL-37341/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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