Document Detail

Baroreflex sensitivity measured by spectral and sequence analysis in cerebrovascular disease : methodological considerations.
MedLine Citation:
PMID:  16770526     Owner:  NLM     Status:  MEDLINE    
Baroreflex sensitivity (BRS) is impaired and of prognostic value in cerebrovascular disease. However, no studies to date have been published on the reproducibility of current methods of measuring BRS in this group. The reproducibility of sequence and spectral analysis methods were therefore assessed in subjects with cerebrovascular disease. A total of 14 subjects were assessed on 2 separate occasions at least 2 weeks apart, and beat-to-beat blood pressure (BP) and ECG trace were recorded for three 5-minute periods. These traces were then analyzed by spectral analysis using Fast Fourier Transform and sequence analysis. Reproducibility was calculated as the coefficient of variation (CV) and reproducibility coefficient (RC). There were no significant differences in heart rate, BP or BRS derived by either method between visits. Reproducibility was CV 22.2%, RC 6.04 ms/mmHg with spectral analysis, and CV 26.3%, RC 7.48 ms/mmHg for sequence analysis. There was close agreement between sequence and spectral derived BRS (r = 0.90). We have demonstrated that the use of spectral and sequence analysis to measure BRS is reproducible in subjects with cerebrovascular disease. These techniques are suitable for follow-up and intervention studies of BRS in this patient group.
Paul Johnson; Angela Shore; John Potter; Ronney Panerai; Martin James
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Publication Detail:
Type:  Journal Article     Date:  2006-06-12
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  16     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-10-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  270-5     Citation Subset:  IM    
Dept. of Medicine for the Elderly, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
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MeSH Terms
Aged, 80 and over
Baroreflex / physiology*
Blood Pressure / physiology
Cerebrovascular Disorders / physiopathology*,  ultrasonography
Middle Aged
Monitoring, Physiologic / methods
Reproducibility of Results
Stroke / physiopathology,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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