Document Detail


Baroreflex sensitivity in essential and secondary hypertension.
MedLine Citation:
PMID:  12598951     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Baroreceptor reflex regulation has been shown to reset towards a higher blood pressure level and to operate with reduced sensitivity in hypertension. Whether this is secondary to elevated blood pressure or whether it plays a role in the development of hypertension is not known. In addition, only limited data exist on baroreflex sensitivity (BRS) in patients with long-lasting medically treated essential hypertension and in patients who have blood pressure elevation with similar severity, but of different etiology. The purpose of this study was to examine BRS in patients with different severity and forms of chronic, medically treated hypertension. Patients with renovascular hypertension (RVHT, n = 14), severe essential hypertension (SEHT, n = 36) and mild essential hypertension (MEHT, n = 29) as well as healthy age- and sex-matched control subjects were studied. BRS was measured with the phenylephrine method.BRS in the RVHT (3.7 +/- 0.6 ms/mmHg) and SEHT (7.6 +/- 0.8 ms/mmHg) groups did not differ from each other after age, gender and left ventricular mass index were taken into consideration. On the contrary, BRS in the RVHT (p = 0.008) and SEHT (p = 0.016) groups were lower than in the MEHT (8.5 +/- 1.2 ms/mmHg) group. BRS was also significantly reduced in the RVHT (P = 0.004) and SEHT groups (P = 0.006) when compared to the healthy age- and sex-matched controls. BRS in the MEHT group did not differ from the control subjects. In conclusion, BRS was equally impaired in patients with renovascular and severe essential hypertension, which was similar in severity but different in etiology. BRS in patients with long-lasting medically treated mild essential hypertension did not differ from the healthy subjects. Our study suggests that baroreflex dysfunction in hypertensive patients is related to the clinical severity of hypertension, rather than its etiology.
Authors:
Hanna Mussalo; Esko Vanninen; Risto Ikäheimo; Tomi Laitinen; Markku Laakso; Esko Länsimies; Juha Hartikainen
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  12     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-07-23     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  465-71     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, P. O. Box 1777, 70211 Kuopio, Finland. Hanna.Mussalo@kuh.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Baroreflex / physiology*
Blood Pressure
Case-Control Studies
Female
Humans
Hypertension / physiopathology*
Hypertension, Renovascular / physiopathology
Male
Middle Aged
Systole
Comments/Corrections
Comment In:
Clin Auton Res. 2002 Dec;12(6):427-8   [PMID:  12607522 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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