Document Detail

Baroreflex sensitivity is impaired in bilateral carotid atherosclerosis.
MedLine Citation:
PMID:  16100025     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The arterial baroreflex is an important determinant of the short-term regulation of blood pressure and cardiovascular variability. The purpose of our study was to determine whether baroreflex sensitivity (BRS) and heart rate (HR) variability are altered in patients with carotid atherosclerosis (CA) and to assess the impact of characteristics of CA on BRS. METHODS: BRS and HR variability were prospectively evaluated in 75 consecutive patients undergoing carotid duplex examination in our neurosonology unit. Resting BRS was measured with the sequence method. HR variability was evaluated using spectral analysis. RESULTS: BRS was significantly reduced in patients with bilateral CA compared with patients without CA (P=0.015) and patients with unilateral CA (P=0.045). BRS was unaltered in patients with unilateral CA compared with patients with no CA. BRS was already reduced in mild (stenosis <50%), bilateral CA and was not further impaired in more severe CA. The association of BRS impairment with bilateral CA remained significant after adjustment for age, hypertension, and a history of stroke or transient ischemic attack. The study of HR variability demonstrated a reduction in the power of high-frequency band in patients with bilateral CA compared with patients with unilateral CA or without CA (P=0.015). CONCLUSIONS: Bilateral CA is associated with an impairment of BRS and a shift of the sympathovagal balance toward a relative decrease of the parasympathetic component of HR variability. These changes are already present in mild, bilateral CA.
Nathalie Nasr; Anne Pavy-Le Traon; Vincent Larrue
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Publication Detail:
Type:  Journal Article     Date:  2005-08-11
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  36     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-25     Completed Date:  2006-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1891-5     Citation Subset:  IM    
Service de Neurologie Vasculaire, Université de Toulouse III, France.
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MeSH Terms
Aged, 80 and over
Aorta, Thoracic / pathology
Atherosclerosis / pathology
Baroreflex / physiology*
Blood Pressure
Blood Pressure Determination
Cardiovascular System
Carotid Arteries / pathology,  ultrasonography
Carotid Artery Diseases / pathology*
Carotid Stenosis / pathology
Heart Rate
Hypertension / pathology
Middle Aged
Prospective Studies
Risk Factors
Sympathetic Nervous System
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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