Document Detail

Baroreflex sensitivity, heart rate, and blood pressure variability in hypertensive pregnancy disorders.
MedLine Citation:
PMID:  15116143     Owner:  NLM     Status:  MEDLINE    
Hypertensive pregnancy disorders are a leading cause of perinatal and maternal morbidity and mortality. Heart rate variability (HRV), blood pressure variability (BPV), and baroreflex sensitivity (BRS) are relevant predictors of cardiovascular risk in humans. The aim of the study was to evaluate whether HRV, BPV, and BRS differ between distinct hypertensive pregnancy disorders. Continuous heart rate and blood pressure recordings were performed in 80 healthy pregnant women as controls (CON), 19 with chronic hypertension (CH), 18 with pregnancy-induced hypertension (PIH), and 44 with pre-eclampsia (PE). The data were assessed by time and frequency domain analysis, nonlinear dynamics, and BRS. BPV is markedly altered in all three groups with hypertensive disorders compared to healthy pregnancies, whereby changes were most pronounced in PE patients. Interestingly, this increase in PE patients did not lead to elevated spontaneous baroreflex events, while BPV changes in both the other hypertensive groups were paralleled by alterations in baroreflex parameters. The HRV is unaltered in CH and PE but significantly impaired in PIH. We conclude that parameters of the HRV, BPV, and BRS differ between various hypertensive pregnancy disorders. Thus, distinct clinical manifestations of hypertension in pregnancy have different pathophysiological, regulatory, and compensatory mechanisms.
R Faber; M Baumert; H Stepan; N Wessel; A Voss; T Walther
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  18     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-23     Completed Date:  2005-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  707-12     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Leipzig, Germany.
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MeSH Terms
Baroreflex / physiology
Blood Pressure
Chronic Disease
Cross-Sectional Studies
Heart Rate / physiology
Hemodynamics / physiology*
Hypertension / diagnosis,  physiopathology*
Hypertension, Pregnancy-Induced / diagnosis,  physiopathology
Monitoring, Physiologic / methods
Pre-Eclampsia / diagnosis,  physiopathology
Predictive Value of Tests
Pregnancy Complications, Cardiovascular / physiopathology*

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