Document Detail


Baroreflex sensitivity alteration following transient hemispheric ischaemia in rats: protective effect of alphamethyldopa and guanfacine.
MedLine Citation:
PMID:  3024888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reflex tachycardia to arterial vasodilation was analysed in anaesthetized and ventilated Long Evans rats. Nicardipine was given by slow intravenous injection. The decrease in blood pressure was accompanied by a sympathetically mediated reflex tachycardia. The slope of the mean blood pressure-pulse period relationship was considered as an index of baroreflex sensitivity. Two injections of nicardipine were given during a single experiment. For studying the suprapontine control of the baroreflex arc, rats were subjected to transient (10 min) bilateral hemispheric ischaemia. These rats exhibited a blood pressure drop following recirculation and baroreflex sensitivity was impaired. Pretreatment with alpha-methyldopa, guanfacine and enalapril lowered mean blood pressure to a similar extent. In those rats pretreated with alpha-methyldopa and guanfacine transient hemispheric ischaemia did not alter baroreflex sensitivity while enalapril pretreated rats exhibited an impaired baroreflex. The protective effect of alpha-methyldopa and guanfacine against the cardiovascular consequence of hemispheric ischaemia may depend on reduced monoamine turnover resulting from central alpha-adrenoceptor stimulation.
Authors:
M A Saad; J L Elghozi; P Meyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  13     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1987-01-28     Completed Date:  1987-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Enalapril / administration & dosage
Guanfacine
Guanidines / pharmacology*
Heart Rate
Ischemic Attack, Transient / physiopathology*
Labetalol / administration & dosage
Male
Methyldopa / pharmacology*
Nicardipine / administration & dosage
Phenylacetates / pharmacology*
Pressoreceptors / drug effects,  physiology*
Rats
Rats, Inbred Strains
Reflex
Tachycardia / chemically induced,  physiopathology
Chemical
Reg. No./Substance:
0/Guanidines; 0/Phenylacetates; 29110-47-2/Guanfacine; 36894-69-6/Labetalol; 555-30-6/Methyldopa; 55985-32-5/Nicardipine; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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