Document Detail

Baroreflex sensitivity alteration following transient hemispheric ischaemia in rats: protective effect of alphamethyldopa and guanfacine.
MedLine Citation:
PMID:  3024888     Owner:  NLM     Status:  MEDLINE    
The reflex tachycardia to arterial vasodilation was analysed in anaesthetized and ventilated Long Evans rats. Nicardipine was given by slow intravenous injection. The decrease in blood pressure was accompanied by a sympathetically mediated reflex tachycardia. The slope of the mean blood pressure-pulse period relationship was considered as an index of baroreflex sensitivity. Two injections of nicardipine were given during a single experiment. For studying the suprapontine control of the baroreflex arc, rats were subjected to transient (10 min) bilateral hemispheric ischaemia. These rats exhibited a blood pressure drop following recirculation and baroreflex sensitivity was impaired. Pretreatment with alpha-methyldopa, guanfacine and enalapril lowered mean blood pressure to a similar extent. In those rats pretreated with alpha-methyldopa and guanfacine transient hemispheric ischaemia did not alter baroreflex sensitivity while enalapril pretreated rats exhibited an impaired baroreflex. The protective effect of alpha-methyldopa and guanfacine against the cardiovascular consequence of hemispheric ischaemia may depend on reduced monoamine turnover resulting from central alpha-adrenoceptor stimulation.
M A Saad; J L Elghozi; P Meyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  13     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1987-01-28     Completed Date:  1987-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-34     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Enalapril / administration & dosage
Guanidines / pharmacology*
Heart Rate
Ischemic Attack, Transient / physiopathology*
Labetalol / administration & dosage
Methyldopa / pharmacology*
Nicardipine / administration & dosage
Phenylacetates / pharmacology*
Pressoreceptors / drug effects,  physiology*
Rats, Inbred Strains
Tachycardia / chemically induced,  physiopathology
Reg. No./Substance:
0/Guanidines; 0/Phenylacetates; 29110-47-2/Guanfacine; 36894-69-6/Labetalol; 555-30-6/Methyldopa; 55985-32-5/Nicardipine; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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