Document Detail


Baroreflex responsiveness in borderline hypertensives: a study with neostigmine.
MedLine Citation:
PMID:  7307028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The baroreflex response to changes in transmural pressure throughout the arterial tree or limited to the carotid sinus was evaluated in ten borderline hypertensives and compared with that observed in ten normal subjects and in ten established hypertensives. Baroreceptor sensitivity was tested by evaluating both heart rate response to phenylephrine-induced increase in arterial pressure and heart rate and blood pressure changes induced by increased neck tissue pressure by means of a neck chamber. The heart rate response to phenylephrine (evaluated by the regression of the R-R interval versus the systolic blood pressure) was depressed both in borderline and established hypertensives as compared with controls. Similarly, the heart rate and the pressor response to increased neck tissue pressure were depressed in both groups of hypertensives. In borderline, but not in established hypertensives, neostigmine administration improved consistently the pressor baroreflex response to increased neck tissue pressure and the heart rate reflex response to both the employed stimuli. These findings indicate that a reduced parasympathetic activity is one of the components involved in the altered baroreflex sensitivity in borderline hypertensives.
Authors:
B Trimarco; M Volpe; B Ricciardelli; C Vigorito; L Sacca; F Rengo; M Condorelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  15     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  436-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Female
Heart Rate / drug effects
Humans
Hypertension / physiopathology*
Male
Middle Aged
Neostigmine / pharmacology*
Parasympathetic Nervous System / physiopathology
Phenylephrine / pharmacology
Physical Stimulation
Pressoreceptors / drug effects,  physiopathology*
Chemical
Reg. No./Substance:
59-42-7/Phenylephrine; 59-99-4/Neostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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