Document Detail

Baroreflex responsiveness in borderline hypertensives: a study with neostigmine.
MedLine Citation:
PMID:  7307028     Owner:  NLM     Status:  MEDLINE    
The baroreflex response to changes in transmural pressure throughout the arterial tree or limited to the carotid sinus was evaluated in ten borderline hypertensives and compared with that observed in ten normal subjects and in ten established hypertensives. Baroreceptor sensitivity was tested by evaluating both heart rate response to phenylephrine-induced increase in arterial pressure and heart rate and blood pressure changes induced by increased neck tissue pressure by means of a neck chamber. The heart rate response to phenylephrine (evaluated by the regression of the R-R interval versus the systolic blood pressure) was depressed both in borderline and established hypertensives as compared with controls. Similarly, the heart rate and the pressor response to increased neck tissue pressure were depressed in both groups of hypertensives. In borderline, but not in established hypertensives, neostigmine administration improved consistently the pressor baroreflex response to increased neck tissue pressure and the heart rate reflex response to both the employed stimuli. These findings indicate that a reduced parasympathetic activity is one of the components involved in the altered baroreflex sensitivity in borderline hypertensives.
B Trimarco; M Volpe; B Ricciardelli; C Vigorito; L Sacca; F Rengo; M Condorelli
Related Documents :
625458 - Phaeochromocytoma with nocturnal elevation of blood pressure.
3084168 - Haemodynamic and humoral reaction in arterial hypertension during acute blood pressure ...
8462138 - Hemodynamic characteristics of the early phase of primary hypertension. the dutch hyper...
3478718 - Intracellular ph in human and experimental hypertension.
9849278 - Lung aeration and pulmonary gas exchange during lumbar epidural anaesthesia and in the ...
6360868 - Time course of development of the antihypertensive effect of propranolol.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  15     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  436-42     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects
Heart Rate / drug effects
Hypertension / physiopathology*
Middle Aged
Neostigmine / pharmacology*
Parasympathetic Nervous System / physiopathology
Phenylephrine / pharmacology
Physical Stimulation
Pressoreceptors / drug effects,  physiopathology*
Reg. No./Substance:
59-42-7/Phenylephrine; 59-99-4/Neostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of timolol on blood flow distribution in the myocardium during acute regional ischaemia in ca...
Next Document:  Transport of radioactive oxygen, nitrogen and xenon into the rabbit thoracic aorta in situ.