Document Detail

Baroreflex responsiveness during hypobaric hypoxia.
MedLine Citation:
PMID:  1905129     Owner:  NLM     Status:  MEDLINE    
Baroreflex responses to graded neck suction during held expiration were studied in five healthy females at sea level and at a simulated altitude of 4,572 m (15,000 ft), with and without oxygen administration. An apparent resetting of the baroreflex was observed during hypobaric hypoxia, but this effect was abolished by oxygen administration. Held expiration alone induced a pulse prolongation in all experimental conditions, however this bradycardiac response was smaller during hypobaric hypoxia than during the two normoxic conditions. When the bradycardic responses of held expiration were subtracted, the baroreflex responses to neck suction were equal in all experimental situations. Similarly, the baroreflex was unaffected by hypobaric hypoxia when the R-R interval prolongations were expressed in percentage of the R-R intervals immediately prior to the neck suction. These data indicate that reduced ambient pressure per se has no influence on the carotid baroreflex control of heart rate.
J Knudtzon; J O Owe; H Aars
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  62     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-07-25     Completed Date:  1991-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM; S    
Institute of Aviation Medicine, Oslo, Norway.
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MeSH Terms
Anoxia / blood,  physiopathology*
Atmospheric Pressure*
Blood Pressure / physiology
Carbon Dioxide / blood
Heart Rate*
Oxygen / blood
Pressoreceptors / physiopathology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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