Document Detail

Baroreflex response and vasodilating drugs in essential hypertension.
MedLine Citation:
PMID:  6822128     Owner:  NLM     Status:  MEDLINE    
Blood pressure, heart rate, and arterial diameter of the brachial artery were studied in patients with sustained essential hypertension before and after administration of three vasodilating drugs: dihydralazine, diltiazem, and dinitrate isosorbide (ISDN). The diameter of the brachial artery was measured using a pulsed Doppler device, enabling the angle between the ultrasound beam and the vessel axis to be evaluated with a precision inferior to 2 percent. The three drugs had similar effects in decreasing the blood pressure and the forearm vascular resistance. Dihydralazine reduced the arterial diameter (p less than 0.001) and increased heart rate. Diltiazem and ISDN increased markedly the arterial diameter (p less than 0.001) but did not change heart rate. Dihydralazine decreased the tangential tension of the arterial wall, while diltiazem and ISDN did not. The study provided evidence that, with vasodilating drugs, the changes in the caliber of peripheral large arteries, which are a determinant of wall arterial tension, can influence the baroreflex-mediated tachycardia caused by use of the drugs.
J A Levenson; M E Safar; J E Bouthier; A M Benetos; A C Simon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  83     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-7     Citation Subset:  AIM; IM    
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MeSH Terms
Benzazepines / therapeutic use*
Blood Pressure / drug effects
Brachial Artery / drug effects
Dihydralazine / therapeutic use*
Diltiazem / therapeutic use*
Heart Rate / drug effects
Hydralazine / analogs & derivatives*
Hypertension / drug therapy*
Isosorbide Dinitrate / therapeutic use*
Middle Aged
Pressoreceptors / drug effects*
Reflex / drug effects*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem; 484-23-1/Dihydralazine; 86-54-4/Hydralazine; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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