Document Detail


Baroreflex function and pressor responsiveness in normotensive young subjects with a family history of hypertension.
MedLine Citation:
PMID:  4068206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Baroreflex control of heart rate, pressor responses to alpha agonist (phenylephrine) and isometric exercise before and during salt loading were compared between 13 normotensive subjects with hypertensive relatives (group A) and 9 normotensive subjects with no family history of hypertension (group B). Baroreflex slope was significantly lower in group A than in group B (9.6 +/- 1.6 vs 17.6 +/- 1.9 msec/mmHg; p less than 0.01), although blood pressure, heart rate and aortic distensibility were not different between two groups. Pressor responses to phenylephrine and isometric exercise were identical for both groups. During salt loading, pressor responses to phenylephrine and isometric exercise were significantly greater in group A than in group B. Baroreflex slope was not affected by salt loading in the two groups. These results suggest that baroreflex control of heart rate is impaired in normotensive young subjects with hypertensive relatives and this defect may be inherited rather than the result of elevated arterial pressure and decreased aortic distensibility. Pressor responses to alpha agonist and isometric exercise during high-sodium diet were augmented in subjects with a family history of hypertension.
Authors:
S Takata; N Iwase; H Okuwa; J Ogawa; T Ikeda; N Hattori
Related Documents :
16339456 - Factors affecting the increased prevalence of erectile dysfunction in greek hypertensiv...
23502646 - Coronary slow flow and abnormal nocturnal blood pressure profile in normotensives.
7895356 - Aging and endothelial function in normotensive subjects and patients with essential hyp...
2848886 - 86rubidium uptake in mononuclear leucocytes from young subjects at increased risk of de...
20921916 - U.s. attitudes and perceived practice for noninvasive ventilation in pediatric acute re...
2302816 - Maintaining speech pressures in the presence of velopharyngeal impairment.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  49     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  990-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure*
Heart Rate
Humans
Hypertension / genetics,  physiopathology*
Isometric Contraction
Phenylephrine / pharmacology
Pressoreceptors / physiology*
Reflex / physiology*
Sodium Chloride / administration & dosage
Stroke Volume
Chemical
Reg. No./Substance:
59-42-7/Phenylephrine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Abnormal renal hemodynamics in salt-sensitive patients with essential hypertension.
Next Document:  Renal denervation inhibits hypothalamo-sympathetic nerve system in normotensive and hypertensive rat...