Document Detail

Baroreflex function: determinants in healthy subjects and disturbances in diabetes, obesity and metabolic syndrome.
MedLine Citation:
PMID:  18220637     Owner:  NLM     Status:  MEDLINE    
Arterial baroreceptors play an important role in the short-term regulation of arterial pressure, by reflex chronotropic effect on the heart and by reflex regulation of sympathetic outflow. Baroreflex sensitivity (BRS) represents an index of arterial baroreceptors function. Several methods of measuring BRS are available nowadays. Different factors influence BRS in the healthy population, including sex, age, blood pressure, heart rate, body fatness, arterial stiffness, blood glucose and insulin levels, as well as physical activity. Baroreceptors dysfunction is evident in diseases such as coronary artery disease, heart failure, arterial hypertension, diabetes mellitus and obesity. The underlying mechanism of BRS attenuation in diabetes or obesity is not yet well known; however, there is increasing evidence that it is at least partly related to autonomic nervous system dysfunction and particularly to sympathetic overactivity that accompanies these diseases. Blunted BRS provides prognostic information for cardiovascular diseases and possibly for diabetes, while its' prognostic information for obesity is not yet established. This review deals with the mechanisms affecting baroreflex function, the newer techniques of BRS estimation and the most recent insights of baroreflex function in the healthy population and in various diseases with emphasis on diabetes and obesity. In addition, the clinical implication of a reduced BRS in these disorders is discussed.
Ioanna Skrapari; Nicholas Tentolouris; Nicholas Katsilambros
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current diabetes reviews     Volume:  2     ISSN:  1573-3998     ISO Abbreviation:  -     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101253260     Medline TA:  Curr Diabetes Rev     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  329-38     Citation Subset:  IM    
1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece.
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MeSH Terms
Baroreflex / physiology*
Blood Pressure / physiology
Brain Stem / physiology
Diabetes Mellitus / physiopathology*
Heart Rate
Hypertension / physiopathology
Metabolic Syndrome X / physiopathology*
Middle Aged
Models, Biological
Obesity / physiopathology*
Reference Values

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