| Baroreflex device therapy in the treatment of hypertension. | |
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MedLine Citation:
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PMID: 19146804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite therapy with multiple optimally dosed medications, hypertension remains poorly controlled in a sizeable number of people worldwide. This has spurred interest in exploring other pharmacologic and nonpharmacologic options for treatment. The carotid baroreceptors are important in regulating blood pressure in chronic hypertension by centrally mediated sympathoinhibitory effects and other effects. This has led to renewed interest in treating hypertension by electrically stimulating the carotid baroreceptors. Although this concept was first studied several decades ago, modern technology and better understanding of physiology have finally allowed the development of a feasible treatment option. Ongoing trials are finding significant and sustained reductions in blood pressure, a good safety profile, and tolerable side-effects. These promising results indicate that this modality has the potential to become a useful tool in future treatment of hypertension. |
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Authors:
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Sarada C Uppuluri; Eugene Storozynsky; John D Bisognano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current hypertension reports Volume: 11 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-16 Completed Date: 2009-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 69-75 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Baroreflex / physiology* Blood Pressure / physiology Carotid Arteries Disease Models, Animal Electric Stimulation Therapy* Humans Hypertension / physiopathology*, therapy* Rats |
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