Document Detail

Baroreflex device therapy in the treatment of hypertension.
MedLine Citation:
PMID:  19146804     Owner:  NLM     Status:  MEDLINE    
Despite therapy with multiple optimally dosed medications, hypertension remains poorly controlled in a sizeable number of people worldwide. This has spurred interest in exploring other pharmacologic and nonpharmacologic options for treatment. The carotid baroreceptors are important in regulating blood pressure in chronic hypertension by centrally mediated sympathoinhibitory effects and other effects. This has led to renewed interest in treating hypertension by electrically stimulating the carotid baroreceptors. Although this concept was first studied several decades ago, modern technology and better understanding of physiology have finally allowed the development of a feasible treatment option. Ongoing trials are finding significant and sustained reductions in blood pressure, a good safety profile, and tolerable side-effects. These promising results indicate that this modality has the potential to become a useful tool in future treatment of hypertension.
Sarada C Uppuluri; Eugene Storozynsky; John D Bisognano
Related Documents :
9356614 - Us-based evaluation of hemodynamic parameters in the common carotid artery: a nomogram ...
1524534 - Attenuation of human carotid-cardiac vagal baroreflex responses after physical detraining.
2520914 - Baroreceptor control after cervical epidural anesthesia in patients undergoing carotid ...
21970544 - High strain-rate brain injury model using submerged acute rat brain tissue slices.
7211744 - Comparison of sodium salicylate, morphine sulfate, and acupuncture at jen-chung (go-26)...
8326614 - Patch graft urethroplasty using dye enhanced laser tissue welding with a human protein ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current hypertension reports     Volume:  11     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Baroreflex / physiology*
Blood Pressure / physiology
Carotid Arteries
Disease Models, Animal
Electric Stimulation Therapy*
Hypertension / physiopathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Angiotensin vaccination: what is the prospect of success?
Next Document:  The hypertension peril: lessons from CETP inhibitors.