Document Detail


Baroreflex device therapy in the treatment of hypertension.
MedLine Citation:
PMID:  19146804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite therapy with multiple optimally dosed medications, hypertension remains poorly controlled in a sizeable number of people worldwide. This has spurred interest in exploring other pharmacologic and nonpharmacologic options for treatment. The carotid baroreceptors are important in regulating blood pressure in chronic hypertension by centrally mediated sympathoinhibitory effects and other effects. This has led to renewed interest in treating hypertension by electrically stimulating the carotid baroreceptors. Although this concept was first studied several decades ago, modern technology and better understanding of physiology have finally allowed the development of a feasible treatment option. Ongoing trials are finding significant and sustained reductions in blood pressure, a good safety profile, and tolerable side-effects. These promising results indicate that this modality has the potential to become a useful tool in future treatment of hypertension.
Authors:
Sarada C Uppuluri; Eugene Storozynsky; John D Bisognano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current hypertension reports     Volume:  11     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / physiology*
Blood Pressure / physiology
Carotid Arteries
Disease Models, Animal
Electric Stimulation Therapy*
Humans
Hypertension / physiopathology*,  therapy*
Rats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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