| Baroreflex control of sympathetic nerve activity in hypertensive pregnant rats with reduced uterine perfusion. | |
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MedLine Citation:
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PMID: 17710579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Baroreflex sensitivity is reduced in women with preeclampsia. The aim of this study was to determine whether baroreflex control of renal sympathetic nerve activity (RSNA) is altered in pregnant rats with reduced uterine perfusion (a model of human preeclampsia). METHODS: Uterine perfusion was reduced in the third trimester by clipping the distal aorta and uterine branches of the ovarian arteries. RSNA baroreflex parameters were compared at term gestation in rats with reduced uterine perfusion (n = 12), in normal pregnant rats (n = 14) and in nonpregnant rats (n = 14). RESULTS: Reduced perfusion rats were hypertensive (123.6 +/- 2.3 mm Hg), and normal pregnant rats were hypotensive (97.7 +/- 2.2 mm Hg), compared with controls. In rats with reduced perfusion, the baroreflex was shifted to a higher set-point, and maximum and minimum RSNA were increased compared with normal pregnant rats. CONCLUSION: The blunted baroreflex gain of normal pregnancy is maintained in rats with reduced uterine perfusion, but a hypertensive shift in baroreflex function exists in this rat model that is associated with a reversal of the reflex maximum and minimum RSNA observed in normal pregnancy. |
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Authors:
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Tina Hines; David Beauchamp; Collin Rice |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 26 ISSN: 1064-1955 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-21 Completed Date: 2007-10-23 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: United States |
Other Details:
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Languages: eng Pagination: 303-14 Citation Subset: IM |
Affiliation:
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University of Missouri-Kansas City School of Nursing, Kansas City, Missouri 64108, USA. hinest@umkc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Baroreflex / physiology* Blood Pressure / physiology* Female Pre-Eclampsia / physiopathology* Pregnancy Rats Regional Blood Flow Sympathetic Nervous System / physiopathology* Uterus / blood supply* |
| Grant Support | |
ID/Acronym/Agency:
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NR004184/NR/NINR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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