Document Detail


Baroreflex control of renal sympathetic nerve activity and spontaneous rhythms at Mayer wave's frequency in rats.
MedLine Citation:
PMID:  15182737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of sedation with pentobarbital sodium (15 mg/kg followed by 15.9+/-1.2 mg/kg/h, i.v.) on arterial pressure (AP) Mayer waves and accompanying oscillations of renal sympathetic nerve activity (RSNA) were examined in rats (n=8). As compared with values observed in the conscious state, pentobarbital significantly (P<0.05) decreased AP (from 119+/-2 to 93+/-3 mm Hg), heart rate (HR; from 427+/-11 to 355+/-11 beats/min) and RSNA (from 1.20+/-0.27 to 0.62+/-0.13 microV). The baroreflex control of RSNA was analyzed by fitting a sigmoid logistic function to changes in RSNA and AP observed during nitroprusside and phenylephrine administrations. During pentobarbital infusion, the RSNA-AP relationship was reset towards lower AP values, but neither its maximum gain nor its gain at resting AP were significantly altered (from 6.3+/-1.0 to 5.8+/-1.4 and from 3.2+/-0.5 to 3.8+/-1.3 normalized units (n.u.)/mm Hg, respectively). Spectral power in the frequency band containing Mayer waves (0.29-0.73 Hz) was significantly decreased by pentobarbital for both AP (from 4.65+/-0.90 to 0.95+/-0.25 mm Hg2) and RSNA (from 1437+/-245 to 488+/-79 n.u.2). This effect was mainly secondary to the attenuation of strongly coherent oscillations of both variables at approximately 0.4 Hz. Although previous experimental evidence points to a major involvement of the sympathetic limb of the arterial baroreceptor reflex in the genesis of Mayer waves, the present study indicates that the amplitude of these oscillations cannot be used as a quantitative index of sympathetic baroreflex sensitivity.
Authors:
Yong Cheng; Benjamin Cohen; Valérie Oréa; Christian Barrès; Claude Julien
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  111     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-06-08     Completed Date:  2004-08-24     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  80-8     Citation Subset:  IM    
Affiliation:
Département de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2678, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon, Cedex 08, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / drug effects,  physiology*
Blood Pressure / drug effects,  physiology*
Hypnotics and Sedatives / pharmacology
Kidney / innervation*
Male
Pentobarbital / pharmacology
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 76-74-4/Pentobarbital

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