Document Detail


Baroreceptor regulation of vasopressin and renin secretion: low-pressure versus high-pressure receptors.
MedLine Citation:
PMID:  7813742     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The high-pressure or arterial baroreceptors and low-pressure or atrial receptors are believed to participate in the reflex control of arginine vasopressin (AVP) and renin secretion. The current concept of the control system is that at normal blood volume and pressure, afferent impulses from the receptors tonically inhibit central mechanisms controlling secretion of AVP and renin. Thus, a reduction in blood volume or pressure causes a decrease in receptor activity and a reflex increase in hormone secretion; conversely an increase in blood volume causes the opposite sequence of events. Furthermore, it is widely believed that cardiac atrial receptors are more important than arterial baroreceptors in the reflex control of AVP and renin secretion. Evidence presented in this review challenges the traditional view that cardiac receptors are importantly involved in the reflex control of AVP secretion. Recent evidence indicates that plasma AVP does not increase during progressive hypovolemia until volume loss causes a frank fall in arterial pressure. Furthermore, the evidence suggests that it is the sudden unloading of arterial baroreceptors that triggers the surge in AVP secretion and not signals from cardiac receptors. There is also very little evidence that increasing the load on cardiac receptors inhibits AVP secretion. In contrast, there is considerable evidence that renal sympathetic nerve activity, and hence reflex control of renin secretion, is tightly and inversely coupled to changes in blood volume. Furthermore, the evidence supports the concept that atrial receptors are the mediators of the fine reflex control of renin secretion in response to changes in blood volume.
Authors:
T N Thrasher
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Frontiers in neuroendocrinology     Volume:  15     ISSN:  0091-3022     ISO Abbreviation:  Front Neuroendocrinol     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513292     Medline TA:  Front Neuroendocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-96     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine, University of California, San Francisco 95143.
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MeSH Terms
Descriptor/Qualifier:
Air Pressure
Animals
Arginine Vasopressin / secretion*
Humans
Pressoreceptors / physiology*
Renin / secretion*
Grant Support
ID/Acronym/Agency:
HL 41156/HL/NHLBI NIH HHS; HL 41313/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
113-79-1/Arginine Vasopressin; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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