Document Detail


Baroreceptor reflex is suppressed in rats that develop hyperalgesia behavior after nerve injury.
MedLine Citation:
PMID:  19729245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The baroreceptor reflex buffers autonomic changes by decreasing sympathetic activity and increasing vagal activity in response to blood pressure elevations, and by the reverse actions when the blood pressure falls. Because of the many bidirectional interactions of pain and autonomic function, we investigated the effect of painful nerve injury by spinal nerve ligation (SNL) on heart rate (HR), blood pressure (BP) and their regulation by the baroreceptor reflex. Rats receiving SNL were separated into either a hyperalgesic group that developed sustained lifting, shaking and grooming of the foot after plantar punctate nociceptive stimulation by pin touch or a group of animals that failed to show this hyperalgesic behavior after SNL. SNL produced no effect on resting BP recorded telemetrically in unrestrained rats compared to control rats receiving either skin incision or sham SNL. However, two tests of baroreceptor gain showed depression only in animals that developed sustained hyperalgesia after SNL. The animals that failed to develop hyperalgesia after SNL were found to have elevations in HR both before and for the first 4 days after SNL, and HR variability analysis gave indications of decreased vagal control of resting HR and elevated sympatho-vagal balance at these same time intervals. In human patients, other research has shown that blunted baroreceptor reflex sensitivity predicts poor outcome during conditions such as hypertension, congestive heart failure, myocardial infarction, and stroke. If baroreceptor reflex suppression is also found in human subjects during chronic neuropathic pain, this may adversely affect survival.
Authors:
Geza Gemes; Marcel Rigaud; Caron Dean; Francis A Hopp; Quinn H Hogan; Jeanne Seagard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-09-02
Journal Detail:
Title:  Pain     Volume:  146     ISSN:  1872-6623     ISO Abbreviation:  Pain     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-26     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  293-300     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / physiology*
Behavior, Animal / physiology
Blood Pressure / physiology
Heart Rate / physiology
Hyperalgesia / physiopathology*,  psychology*
Ligation
Male
Phenylephrine / pharmacology
Rats
Rats, Sprague-Dawley
Rest
Spinal Nerves / injuries*
Telemetry
Vasoconstrictor Agents / pharmacology
Grant Support
ID/Acronym/Agency:
NS-42150/NS/NINDS NIH HHS; R01 NS042150/NS/NINDS NIH HHS; R01 NS042150-07/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 1WS297W6MV/Phenylephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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