Document Detail


Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension.
MedLine Citation:
PMID:  472749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raised by an infusion of phenylephrine, rats showed less running to terminate or avoid noxious stimuli than during saline infusions. This effect was not seen in rats with denervated baroreceptors. The results suggest that a rise of blood pressure could have motivational consequences significant for human hypertension.
Authors:
B R Dworkin; R J Filewich; N E Miller; N Craigmyle; T G Pickering
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  205     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1299-301     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / drug effects,  physiology*
Blood Pressure / drug effects
Heart Rate / drug effects
Hypertension / physiopathology*
Male
Motivation / physiology
Phenylephrine / pharmacology
Pressoreceptors / physiology*
Rats
Chemical
Reg. No./Substance:
59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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