Document Detail

Barmah Forest virus serology; implications for diagnosis and public health action.
MedLine Citation:
PMID:  18767428     Owner:  NLM     Status:  MEDLINE    
Barmah Forest virus (BFV) is a commonly occurring arbovirus in Australia. Notifications of Barmah Forest infections diagnosed by a single positive IgM serology test have been increasing in coastal New South Wales north of Newcastle. We report on a 6 month prospective review of all routine notifications of BFV from the Lower Mid North Coast of New South Wales. Sera from 37 consecutive cases were sent for confirmatory testing by ELISA and neutralisation assays and 32 cases were interviewed. On confirmatory testing, 7 patients' sera (19%) was found to contain no BFV antibodies and 6 (16%) had BFV IgG only. Only 4 cases had antibody levels compatible with recent infection. A clinical presentation of fever with either rash or joint pain was associated with confirmation of recent BFV infection. On the basis of these findings, caution is advised in the interpretation of a single positive IgM for Barmah Forest disease and the clinical picture is an important factor in the diagnosis. Serological notifications of BFV alone should not prompt public health action such as public warning and targeted vector control in endemic areas.
Patrick Cashman; Linda Hueston; David Durrheim; Peter Massey; Stephen Doggett; Richard C Russell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Communicable diseases intelligence quarterly report     Volume:  32     ISSN:  1447-4514     ISO Abbreviation:  Commun Dis Intell Q Rep     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-10-28     Revised Date:  2013-10-29    
Medline Journal Info:
Nlm Unique ID:  101601804     Medline TA:  Commun Dis Intell Q Rep     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  263-6     Citation Subset:  IM    
Health Protection, Hunter New England Population Health Unit, Hunter New England Area Health Service, New South Wales.
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MeSH Terms
Alphavirus / isolation & purification*
Alphavirus Infections / blood*,  diagnosis,  epidemiology,  immunology*
Antibodies, Viral / blood
Disease Notification
Immunoglobulin G / blood
Immunoglobulin M / blood
Neutralization Tests
New South Wales / epidemiology
Public Health*
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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