Document Detail


Bariatric surgery improves atherogenic LDL profile by triglyceride reduction.
MedLine Citation:
PMID:  18780133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Small dense low-density lipoprotein (LDL) are atherogenic particles frequently observed in obese patients. Fatty acids modulate LDL. Objective of this study was to determine the relations between plasma phospholipid fatty acid composition and the presence of small dense LDL particles in morbidly obese patients treated with laparoscopic gastric banding (LAGB). METHODS: Small dense LDL, plasma lipids, lipoproteins, apoproteins, and phospholipid fatty acid composition (a marker of dietary fatty acid intake) were quantified before and 12 months after surgery in four men and 11 women who were morbidly obese and (BMI > 40 kg/m(2)) eligible for surgery, consecutively treated with LAGB at the Department of Medical and Surgical Sciences of the University of Padova. RESULTS: BMI was 48.3 +/- 4.8 kg/m(2) before and 36.1 +/- 5.5 kg/m(2) after LAGB. Plasma triglycerides and apoprotein E levels significantly decreased, while HDL cholesterol significantly increased after LAGB. A reduction of small dense LDL with an increase of LDL relative flotation (0.34 +/- 0.04 before vs 0.38 +/- 0.03 after LAGB, p < 0.001) was also observed. These modifications were neither related to weight reduction nor to changes in phospholipid fatty acid composition, but they were associated to triglyceride reduction, which explained 76.7% of the LDL relative flotation variation. CONCLUSION: Weight loss obtained by LAGB in morbidly obese subjects was accompanied by triglyceride reduction, high-density lipoprotein increase, and an improvement of the atherogenic LDL profile. Triglyceride reduction, but not the extent of weight loss or dietary fatty acid modifications, is the determinant of modifications of LDL physical properties in these patients.
Authors:
Sabina Zambon; Giovanna Romanato; Giovanni Sartore; Raffaella Marin; Luca Busetto; Silvia Zanoni; Franco Favretti; Giuseppe Sergi; Paola Fioretto; Enzo Manzato
Related Documents :
8157583 - Fatty acids of treponema pallidum and borrelia burgdorferi lipoproteins.
3356683 - The effect of triacyl-sn-glycerol structure on the metabolism of chylomicrons and triac...
239413 - Effect of release of endogenous gastrin on myoelectrical and mechanical activity of iso...
Publication Detail:
Type:  Journal Article     Date:  2008-09-09
Journal Detail:
Title:  Obesity surgery     Volume:  19     ISSN:  0960-8923     ISO Abbreviation:  Obes Surg     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106714     Medline TA:  Obes Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-5     Citation Subset:  IM    
Affiliation:
Department of Medical and Surgical Sciences, University of Padova, via Giustiniani, 2, 35128 Padova, Italy. sabina.zambon@unipd.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Gastroplasty / methods*
Humans
Laparoscopy*
Lipoproteins, LDL / blood*
Male
Middle Aged
Obesity, Morbid / blood,  surgery*
Treatment Outcome
Triglycerides / blood*
Weight Loss
Young Adult
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The impact of weight loss on cardiac structure and function in obese patients.
Next Document:  Use of a dual mobility socket to manage total hip arthroplasty instability.