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Bariatric surgery following treatment for craniopharyngioma: a systematic review and individual-level data meta-analysis.
MedLine Citation:
PMID:  23533238     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives:Craniopharyngiomas are rare low-grade tumors located in the hypothalamic or/and the pituitary region. Hypothalamic involvement and treatment resulting in hypothalamic damage are known to lead to development of "hypothalamic" obesity (HyOb) in 50% of cases. The management of HyOb, associated with eating disorders and rapid comorbidities, is an important issue. Bariatric surgery is the most effective therapy for weight loss in patients with severe exogenous obesity. The aim of this systematic review and meta-analysis was to determine the 12 month outcome of bariatric surgery for HyOb due to craniopharyngioma treatment.Methods and Results:Relevant studies were identified by searches of the MEDLINE and EMBASE databases until January 2013. A total of 21 cases were included: 6 with adjustable gastric banding, 8 with sleeve gastrectomy, 6 with Roux en Y gastric bypass, and 1 with biliopancreatic diversion. After data pooling, mean weight difference was -20.9 kg after 6 months [95% CI: - 35.4, -6.3] and -15.1 kg after 12 months [95% CI: -31.7, +1.4]. The maximal mean weight loss was achieved by the gastric bypass group: -31.0 kg [95% CI: -77.5, +15.5] and -33.7 kg [95% CI: -80.7, +13.3] after 6 and 12 months, respectively.Conclusions:In this largest ever published study on the effect of bariatric surgery on obesity following craniopharyngioma treatment, we observed an important weight loss after one year of follow-up. Larger studies are warranted to establish appropriate selection criteria and the best surgical technique to perform bariatric surgery.
Authors:
Marion Bretault; Adrien Boillot; Ludivine Muzard; Christine Poitou; Jean-Michel Oppert; Charles Barsamian; Blandine Gatta; Herman Müller; Dirk Weismann; Diane Rottembourg; Thomas Inge; Nicolas Veyrie; Claire Carette; Sébastien Czernichow
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-26
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Nutrition, Ambroise Paré Hospital (AP-HP); University of Versailles St Quentin en Yvelines, 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France;
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