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Bare-metal stent versus drug-eluting stent in large coronary arteries: meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  22899538     Owner:  NLM     Status:  Publisher    
BACKGROUND: Uncertainties exist with regard to the efficacy of drug-eluting stent (DES) versus bare-metal stent (BMS) in large coronary arteries. OBJECTIVE AND METHODS: The aim of this study was to investigate the efficacy of BMS versus DES in terms of clinical events in large coronary vessels (≥ 3.0 mm) by performing a meta-analysis of all relevant randomized controlled trials (RCTs). RESULTS: Six RCTs with 4,399 patients were included in this study. Overall, there were no significant between-group differences in the risks of the composite of cardiac death and non-fatal myocardial infarction (cardiac death/MI), cardiac death, myocardial infarction, and stent thrombosis, however, DES was associated with significant reduction in the risk of target vessel revascularization (TVR) compared to BMS [0.48 (0.33, 0.70)] with consistent benefits among patients with reference vessel diameter ≥ 3.5 mm, reference vessel diameter ≥ 4.0 mm, stent length ≤ 15 mm, first-generation DES or second-generation DES. In patients with ≥ 3-year follow-up, there were no significant between-group differences in the risk of cardiac death/MI, TVR, cardiac death, myocardial infarction or stent thrombosis. CONCLUSIONS: This meta-analysis suggests that DES is superior to BMS in terms of adverse cardiac events in large coronary arteries at the mid-term follow-up. The long-term efficacy of newer-generation DES versus BMS in larger coronary arteries is still worth further evaluation. © 2012 Wiley Periodicals, Inc.
Deng-Feng Geng; Zhe Meng; Hai-Yan Yan; Ru-Qiong Nie; Jing Deng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-17
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology; Guangzhou 510120, China.
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