Document Detail


Bare, bio-active and hydrogel-coated coils for endovascular treatment of experimentally induced aneurysms. Long-term histological and scanning electron microscopy results.
MedLine Citation:
PMID:  20642888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endovascular treatments of cerebral aneurysms with bare platinum coils have a higher rate of recurrence compared to surgical clipping. This may be related to failed vessel wall reconstruction since histological and scanning electron microscopy results following embolization failed to demonstrate neoendothelialization over the aneurysm neck. The present study tried to elucidate whether the use of modified coils resulted in a better rate of reconstructing the vessel wall over the aneurysm neck in experimental aneurysms. Aneurysms were created in 20 rabbits by intraluminal elastase incubation of the common carotid artery. Five animals each were assigned to the following groups: untreated, bare platinum coils, bioactive coils with polyglycolic/polylactic acid coating, and hydrogel-coated platinum coils. After 12 months, angiography, histology and scanning electron microscopy was performed. No neoendothelial layer was visualized in the bioactive and bare coil groups with a tendency to an increased layering of fibroblasts along the bioactive coils at the aneurysm fundus. However, at the aneurysm neck perfused clefts were present and although a thin fibrinous layer was present over some coils, no bridging neointimal or neoendothial layer was noted over different coils. Following loose Hydrogel coiling, a complete obliteration of the aneurysm was present with neoendothelialization present over different coil loops. The study demonstrates that with surface coil modifications complete and stable aneurysm obliteration may become possible. A smooth and dense surface over the aneurysm neck may be necessary for endothelial cells to bridge the aneurysm neck and to lead to vessel wall reconstruction.
Authors:
M H T Reinges; T Krings; A Y Drexler; A Ludolph; B Sellhaus; M Bovi; S Geibprasert; R Agid; K Scherer; F J Hans
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Publication Detail:
Type:  Journal Article     Date:  2010-07-19
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  16     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-10-07     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  139-50     Citation Subset:  IM    
Affiliation:
University Hospital of the University of Technology, Aachen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carotid Artery Diseases / pathology,  radiography,  therapy
Coated Materials, Biocompatible / pharmacology*
Disease Models, Animal
Embolization, Therapeutic / instrumentation*,  methods*
Endothelium, Vascular / pathology
Hydrogel / pharmacology*
Intracranial Aneurysm / pathology,  radiography,  therapy*
Microscopy, Electron, Scanning
Platinum
Rabbits
Tunica Intima / pathology,  ultrastructure
Wound Healing
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible; 25852-47-5/Hydrogel; 7440-06-4/Platinum
Comments/Corrections

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