| Barbiturates, smoking, and bladder cancer risk. | |
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MedLine Citation:
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PMID: 9829715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phenobarbital treatment has been observed to be negatively associated with bladder cancer risk in a few studies. It has been suggested that phenobarbital may induce drug-metabolizing enzymes that detoxify the bladder carcinogens found in cigarette smoke. We examined the relationship of barbiturate use to bladder cancer risk and the potential modifying effect of cigarette smoking in a large cohort of Kaiser Permanente Medical Care Program members with computerized pharmacy prescriptions and smoking information. Newly diagnosed bladder cancers were identified among individuals in the study cohort by linkage with data from cancer registries. The overall standardized incidence ratio associated with barbiturate use was 0.71 [95% confidence interval (CI), 0.51-0.99]. Among current smokers, former smokers, and never smokers, the standardized incidence ratios were 0.56 (95% CI, 0.23-1.16), 0.68 (95% CI, 0.27-1.40), and 1.04 (95% CI, 0.48-1.98), respectively. Although our estimates were imprecise, the finding of an inverse association between barbiturate treatment and bladder cancer risk only among current and former cigarette smokers is consistent with the hypothesis that treatment with these medications induces drug-metabolizing enzymes that deactivate bladder carcinogens found in cigarette smoke. |
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Authors:
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L A Habel; S A Bull; G D Friedman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 7 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-27 Completed Date: 1999-01-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1049-50 Citation Subset: IM |
Affiliation:
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Division of Research, Kaiser Permanente Medical Care Program, Oakland, California 94611, USA. lah@dor.kaiser.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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California
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epidemiology Cohort Studies Humans Hypnotics and Sedatives / therapeutic use* Incidence Phenobarbital / therapeutic use* Risk Factors Smoking / adverse effects* Urinary Bladder Neoplasms / epidemiology*, prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
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R35 CA 49761/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 50-06-6/Phenobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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